Cancer is a disease arising from both genetic and epigenetic modifications of DNA that
contribute to changes in gene expression in the cell. Genetic modifications include loss or …

Cervical cancer remains one of the greatest killers of women worldwide. It is difficult to
foresee a dramatic increase in cure rate even with the most optimal combination of cytotoxic …

The cancer epigenome is characterised by specific DNA methylation and chromatin
modification patterns. The proteins that mediate these changes are encoded by the …

Purpose: Epigenetic modifications of histone have crucial roles in the control of gene activity,
nuclear architecture, and genomic stability. In this respect, they may contribute to the …

Background Post-translational modification of histones resulting in chromatin remodelling
plays a key role in the regulation of gene expression. Here we report characteristic patterns …

Epigenetic deregulation of gene expression has a role in the initiation and progression of
prostate cancer (PCa). The histone methyltransferase MMSET/WHSC1 (Multiple Myeloma …

Increased glucose metabolism in cancer cells is a phenomenon that has been known for
over 90 years, allowing maximal cell growth through faster ATP production and redistribution …

Individual cells within a tumour can exhibit distinct genetic and molecular features. The
impact of such diversification on metastatic potential is unknown. Here we identify clonal …

Malignant ovarian tumors bear the highest mortality rate among all gynecological cancers.
Both late tumor diagnosis and tolerance to available chemical therapy increase patient …

OBJECTIVE—The complexity of interactions between genes and the environment is a major
challenge for type 1 diabetes studies. Nuclear chromatin is the interface between genetics …