Epigenetic mechanisms control eukaryotic development beyond DNA‐stored information.
There are several pathways, including histone tail modifications, histone variant …

Disruption of the histone modification patterns is one of the most common features of human
tumors. However, few genetic alterations in the histone modifier genes have been described …

The aberrant epigenetic landscape of a cancer cell is characterized by global genomic
hypomethylation, CpG island promoter hypermethylation of tumor suppressor genes, and …

Oxygen is both an environmental and developmental signal that governs important cellular
pathways. Therefore, hypoxia (or low oxygen tensions) is part of both physiological and …

Bone remodeling is a continuous and dynamic process of bone formation and resorption to
maintain its integrity and homeostasis. Bone marrow is a source of various cell lineages …

Although the involvement of protein arginine methyltransferase 1 (PRMT1) in tumorigenesis
has been reported, its roles in breast cancer progression and metastasis has not been …

Cancer is one of the most common human diseases. It is long known that mutations in key
regulator genes are hallmarks of all cancer types. Apart from these classical genetic …

p300 acts as a transcription coactivator and an acetyltransferase that plays an important role
in tumourigenesis and progression. In previous studies, it has been confirmed that p300 is …

Cancer is nowadays recognised as a genetic and epigenetic disease. Much effort has been
devoted in the last 30 years to the elucidation of the 'classical'oncogenes and tumour …

Adenovirus small early region 1a (e1a) protein drives cells into S phase by binding RB
family proteins and the closely related histone acetyl transferases p300 and CBP. The …