CONTEXT: Prostate cancer (PCa) is one of the most common human malignancies and
arises through genetic and epigenetic alterations. Epigenetic modifications include DNA …

Histone modifications play critical roles in the epigenetic regulation of gene expression and
in the maintenance of genome integrity. Acetylation and methylation of histone H3 are …

Methylation of lysine 27 on histone H3 (H3K27) by the EZH2 complex is an epigenetic mark
that mediates gene silencing. EZH2 is overexpressed in many cancers and correlates with …

Deciphering the epigenetic" code" remains a central issue in transcriptional regulation.
Here, we report the identification of a JAMM/MPN+ domain-containing histone H2A …

In castration-resistant prostate cancer (CRPC), clinical response to androgen receptor (AR)
antagonists is limited mainly due to AR-variants expression and restored AR signaling. The …

Epigenetics is rising to prominence in biology as a mechanism by which environmental
factors have intermediate-term effects on gene expression without changing the underlying …

Genetic information is packaged in the highly dynamic nucleoprotein structure called
chromatin. Many biological processes are regulated via post-translational modifications of …

Epigenetic dysregulation is being increasingly recognized as a hallmark of cancer. Post-
translational modifications of histones, in particular, are known to play important roles gene …

The transformation of normal cells into cancer cells and maintenance of the malignant state
and phenotypes are associated with genetic and epigenetic deregulations, altered cellular …

Disruption of histone acetylation patterns is a common feature of cancer cells, but very little
is known about its genetic basis. We have identified truncating mutations in one of the …