DC Johnson, DR Dean, AD Smith… - Annu. Rev …, 2005 - annualreviews.org
▪ Abstract Iron-sulfur [Fe-S] clusters are ubiquitous and evolutionary ancient prosthetic groups that are required to sustain fundamental life processes. Owing to their remarkable …
The focus of this review is the human de novo purine biosynthetic pathway. The pathway enzymes are enumerated, as well as the reactions they catalyze and their physical …
G Dodson, A Wlodawer - Trends in biochemical sciences, 1998 - cell.com
Interactions among the residues in the serine protease Asp-His–Ser catalytic triad, in the special environment of the enzyme–substrate complex, activate the nucleophilic potential of …
L Polgár - Cellular and molecular life sciences CMLS, 2005 - Springer
The catalytic action of serine peptidases depends on the interplay of a nucleophile, a general base and an acid. In the classic trypsin and subtilisin families this catalytic triad is …
THE crystal structures of three amidohydrolases have been determined recently1–3: glutamine PRPP amidotransferase (GAT), penicillin acylase, and the proteasome. These …
HC Pace, C Brenner - Genome biology, 2001 - Springer
The nitrilase superfamily consists of thiol enzymes involved in natural product biosynthesis and post-translational modification in plants, animals, fungi and certain prokaryotes. On the …
A Carfi, S Pares, E Duee, M Galleni, C Duez… - The EMBO …, 1995 - embopress.org
The 3‐D structure of Bacillus cereus (569/H/9) beta‐lactamase (EC 3.5. 2.6), which catalyses the hydrolysis of nearly all beta‐lactams, has been solved at 2.5 A resolution by …
M Bochtler, L Ditzel, M Groll… - Annual review of …, 1999 - annualreviews.org
▪ Abstract Proteasomes are large multisubunit proteases that are found in the cytosol, both free and attached to the endoplasmic reticulum, and in the nucleus of eukaryotic cells. Their …