Energy-driven genome regulation by ATP-dependent chromatin remodellers
The packaging of DNA into chromatin in eukaryotes regulates gene transcription, DNA
replication and DNA repair. ATP-dependent chromatin remodelling enzymes (re) arrange …
replication and DNA repair. ATP-dependent chromatin remodelling enzymes (re) arrange …
Chemoenzymatic semisynthesis of proteins
RE Thompson, TW Muir - Chemical reviews, 2019 - ACS Publications
Protein semisynthesis—defined herein as the assembly of a protein from a combination of
synthetic and recombinant fragments—is a burgeoning field of chemical biology that has …
synthetic and recombinant fragments—is a burgeoning field of chemical biology that has …
[HTML][HTML] Histone dynamics mediate DNA unwrapping and sliding in nucleosomes
GA Armeev, AS Kniazeva, GA Komarova… - Nature …, 2021 - nature.com
Nucleosomes are elementary building blocks of chromatin in eukaryotes. They tightly
wrap∼ 147 DNA base pairs around an octamer of histone proteins. How nucleosome …
wrap∼ 147 DNA base pairs around an octamer of histone proteins. How nucleosome …
Structure and function of chromatin remodelers
AA Reyes, RD Marcum, Y He - Journal of molecular biology, 2021 - Elsevier
Chromatin remodelers act to regulate multiple cellular processes, such as transcription and
DNA repair, by controlling access to genomic DNA. Four families of chromatin remodelers …
DNA repair, by controlling access to genomic DNA. Four families of chromatin remodelers …
[HTML][HTML] Human SMARCA5 is continuously required to maintain nucleosome spacing
Genetic models suggested that SMARCA5 was required for DNA-templated events including
transcription, DNA replication, and DNA repair. We engineered a degron tag into the …
transcription, DNA replication, and DNA repair. We engineered a degron tag into the …
Structure of the RSC complex bound to the nucleosome
The RSC complex remodels chromatin structure and regulates gene transcription. We used
cryo–electron microscopy to determine the structure of yeast RSC bound to the nucleosome …
cryo–electron microscopy to determine the structure of yeast RSC bound to the nucleosome …
Bi-directional nucleosome sliding by the Chd1 chromatin remodeler integrates intrinsic sequence-dependent and ATP-dependent nucleosome positioning
Chromatin remodelers use a helicase-type ATPase motor to shift DNA around the histone
core. Although not directly reading out the DNA sequence, some chromatin remodelers …
core. Although not directly reading out the DNA sequence, some chromatin remodelers …
Single-molecule analysis and engineering of DNA motors
Molecular motors are diverse enzymes that transduce chemical energy into mechanical
work and, in doing so, perform critical cellular functions such as DNA replication and …
work and, in doing so, perform critical cellular functions such as DNA replication and …
Sequence specificity in DNA binding is mainly governed by association
Sequence-specific binding of proteins to DNA is essential for accessing genetic information.
We derive a model that predicts an anticorrelation between the macroscopic association and …
We derive a model that predicts an anticorrelation between the macroscopic association and …
Biophysics of chromatin remodeling
IM Nodelman, GD Bowman - Annual review of biophysics, 2021 - annualreviews.org
As primary carriers of epigenetic information and gatekeepers of genomic DNA,
nucleosomes are essential for proper growth and development of all eukaryotic cells …
nucleosomes are essential for proper growth and development of all eukaryotic cells …