There is new and increasing evidence from in vitro, in vivo and clinical studies implicating
the pivotal role of iron and associated metabolic pathways in the initiation, progression and …

The need for preparing new strategies for the design of emergency drug therapies against
COVID-19 and similar diseases in the future is rather urgent, considering the high rate of …

The main factor contributing to various fatal pulmonary diseases, including asthma,
pneumonia, pneumocystis, COPD, lung cancer and pulmonary fibrosis, is inflammation [1]. A …

Aquaporin-1 (AQP1), a water channel, and the hypoxia-inducible factor 1α (HIF1A) are
implicated in acute lung injury responses, modulating among others pulmonary vascular …

COPD is a heterogeneous disease with multiple clinical phenotypes. COPD endotypes can
be determined by different expressions of hypoxia-inducible factors (HIFs), which, in …

There are currently no effective treatments for sepsis and acute respiratory distress
syndrome (ARDS). The repositioning of existing drugs is one possible effective strategy for …

牦牛广泛分布于海拔3000~ 5000m 的高原地区, 是当地畜牧业经济发展的重要畜种.
经过长期适应性进化, 牦牛在生理结构以及遗传分子方面表现出高原适应性特征 …

We previously identified a missense single nucleotide polymorphism rs2228315 (G> A,
Met62Ile) in the selectin‐P‐ligand gene (SELPLG), encoding P‐selectin glycoprotein ligand …

The human respiratory and circulatory systems collaborate intricately to ensure oxygen
delivery to all cells, which is vital for ATP production and maintaining physiological functions …

Pre-hospital potentially preventable trauma related deaths are mainly due to hypoperfusion-
induced tissue hypoxia leading to irreversible organ dysfunction at or near the point of injury …