Neurotrophic assays are phenotypic methods to identify molecules that stimulate
differentiation of neuronal cells. Bioactive small molecules with neurotrophic actions hold …

Intrachromosomal amplification of chromosome 21 (iAMP21) is a cytogenetic subtype
associated with relapse and poor prognosis in pediatric B-cell precursor acute lymphoblastic …

DYRK1A, the dual-specificity kinase, is again doubling up on function, as reported by
Bhansali, Rammohan, and colleagues in this issue of the JCI. DYRK1A is an evolutionarily …

Deregulation of dual‐specificity tyrosine phosphorylation‐regulated kinase 1A (DYRK1A)
plays a significant role in developmental brain defects, early‐onset neurodegeneration …

Modifications at the harmine (HAM) 9‐N position demonstrated effective antitumor activity in
previous studies. However, the difficult preparation, low yield and poor stability of derivatives …

Multisite phosphorylations on a single polypeptide mediated by protein kinase (s) are
commonly observed. In some cases, hierarchical phosphorylations occur when first priming …

Background: Virtual screening is vital for contemporary drug discovery but striking
performance fluctuations are commonly encountered, thus hampering error-free use …

A series of new pyrazolo [3, 4-c] pyridines bearing various 1, 3, 5 or 1, 3, 7 pattern
substitutions, were designed and synthesized. Some of them showed interesting inhibitory …

The pathogenic mechanism underlying Parkinson's disease (PD) and PD-Cognitive
impairment (CI) remains elusive. Its potential link to the risk factors in Alzheimer's disease …

While protein tyrosine kinases (PTKs) play an initiative role in growth factor-mediated
cellular processes, protein tyrosine phosphatases (PTPs) negatively regulates these …