Sulfur is widely existent in natural products and synthetic organic compounds as
organosulfur, which are often associated with a multitude of biological activities …

90% of genes in the human body undergo alternative splicing (AS) after transcription, which
enriches protein species and regulates protein levels. However, there is growing evidence …

Growing evidence indicates that protein synthesis is deregulated in cancer onset and
progression and targeting this process might be a selective way to combat cancers. While …

β‐Cell dysfunction in type 1 and type 2 diabetes is accompanied by a progressive loss of β‐
cells, and an understanding of the cellular mechanism (s) that regulate β‐cell mass will …

Simple Summary CMGC kinases, named after the initials of its main kinase families, C DKs,
M APKs, G SKs, and C LKs, play critical roles in many cellular processes. Dysregulation of …

Children with Down syndrome (DS) are at a 20-fold increased risk for acute lymphoblastic
leukemia (DS-ALL). Although the etiology of this higher risk of developing leukemia remains …

The DYRK family contains kinases that are up-regulated in malignancy and control several
cancer hallmarks. To assess the anticancer potential of inhibitors targeting DYRK kinases …

Abstract Cdc2-like kinase 1 (CLK1) and dual specificity tyrosine phosphorylation-regulated
kinase 1A (DYRK1A) are involved in the regulation of alternative pre-mRNA splicing …

Cancer cells metabolize different energy sources to generate biomass rapidly. The purine
biosynthetic pathway was recently identified as an important source of metabolic …

The protein kinase DYRK1A is involved in Alzheimer's disease, Down syndrome, diabetes,
viral infections, and leukemia. Leucettines, a family of 2-aminoimidazolin-4-ones derived …