Protein aggregation and oxidative stress are two pathological hallmarks of a number of
protein misfolding diseases, including Huntington's disease (HD). Whether protein …

Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is a protein kinase
with diverse functions in cell regulation. Abnormal expression and activity of DYRK1A …

Here we report two new artificial pseudopeptidic cages that bind the EYE peptide epitope in
pure water at physiological pH (as studied by fluorescence and NMR spectroscopies). The …

The inverse association between Alzheimer's disease (AD) and cancer has been reported in
several population-based studies although both of them are age-related disorders …

In the microalga Euglena gracilis, the storage polysaccharide paramylon (β-1, 3-D-glucan) is
degraded to glucose, and finally converted to wax esters under anaerobic conditions. The …

Harmal: The Genus Peganum is an in-depth treatment of one of the most commanding
plants in the botanical kingdom. Humble in appearance, modest in its needs, Peganum …

DYRK1B, has been recently recognized as a critical therapeutic target in oncology,
metabolic syndrome, and non-alcoholic fatty liver disease. However, the development of …

Glioblastoma multiforme and medulloblastoma are the most frequent high-grade brain
tumors in adults and children, respectively. Standard therapies for these cancers are mainly …

Abstract Phosphoinositide 3-kinase (PI3Ks) are lipid kinases widely involved in cell
proliferation, metastasis and differentiation. Constitutive activation of the PI3K/Akt/mTOR …

Liver fibrosis is a major consequence of chronic liver disease, where excess extracellular
matrix is deposited, due caused by the activation of hepatic stellate cells (HSCs). The …