Alzheimer's disease (AD) is a major public health problem with substantial economic and
social impacts around the world. The hallmarks of AD pathogenesis include deposition of …

Toll-like receptors (TLRs) are components of the innate immune system that respond to
exogenous infectious ligands (pathogen-associated molecular patterns, PAMPs) and …

Microglia, the major myeloid cells of the central nervous system (CNS) are implicated in
physiologic processes and in the pathogenesis of several CNS disorders. Since their initial …

Rationale: A hallmark of chronic inflammatory disorders is persistence of proinflammatory
macrophages in diseased tissues. In atherosclerosis, this is associated with dyslipidemia …

Introduction• TLR signalling• Endogenous TLR ligands• Biological significance of signalling
triggered by endogenous TLR ligands‐Ischemia and reperfusion injury‐Tissue repair and …

Alzheimer's disease is the world's most common neurodegenerative disorder. It is
associated with neuroinflammation involving activation of microglia by β-amyloid (Aβ) …

The CANTOS (Canakinumab Anti-inflammatory Thrombosis Outcome Study) and colchicine
trials suggest an important role of inflammasomes and their major product IL-1β (interleukin …

Alzheimer's disease (AD) is the most common neurodegenerative disease worldwide.
Histopathologically, AD presents with two hallmarks: neurofibrillary tangles (NFTs), and …

Background and Aims Fatty acid translocase CD36 (CD36) is a membrane protein with
multiple immuno-metabolic functions. Palmitoylation has been suggested to regulate the …

Heme is an essential molecule expressed ubiquitously all through our tissues. Heme plays
major functions in cellular physiology and metabolism as the prosthetic group of diverse …