Redox control of inflammation in macrophages

B Brüne, N Dehne, N Grossmann, M Jung… - Antioxidants & redox …, 2013 - liebertpub.com
Macrophages are present throughout the human body, constitute important immune effector
cells, and have variable roles in a great number of pathological, but also physiological …

Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential

ML Hanke, T Kielian - Clinical science, 2011 - portlandpress.com
The discovery of mammalian TLRs (Toll-like receptors), first identified in 1997 based on their
homology with Drosophila Toll, greatly altered our understanding of how the innate immune …

Alzheimer's disease as an inflammatory disease

M Bolós, JR Perea, J Avila - Biomolecular concepts, 2017 - degruyter.com
Alzheimer's disease (AD) is a neurodegenerative condition characterized by the formation of
amyloid-β plaques, aggregated and hyperphosphorylated tau protein, activated microglia …

Microglia in Alzheimer's disease: Pathogenesis, mechanisms, and therapeutic potentials

J Miao, H Ma, Y Yang, Y Liao, C Lin, J Zheng… - Frontiers in aging …, 2023 - frontiersin.org
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by protein
aggregation in the brain. Recent studies have revealed the critical role of microglia in AD …

Parasite recognition and signaling mechanisms in innate immune responses to malaria

DC Gowda, X Wu - Frontiers in immunology, 2018 - frontiersin.org
Malaria caused by the Plasmodium family of parasites, especially P. falciparum and P. vivax,
is a major health problem in many countries in the tropical and subtropical regions of the …

The complexity of neuroinflammation consequent to traumatic brain injury: from research evidence to potential treatments

MC Morganti-Kossmann, BD Semple, SC Hellewell… - Acta …, 2019 - Springer
This review recounts the definitions and research evidence supporting the multifaceted roles
of neuroinflammation in the injured brain following trauma. We summarise the literature …

Amyloid-β receptors: the good, the bad, and the prion protein

HH Jarosz-Griffiths, E Noble, JV Rushworth… - Journal of biological …, 2016 - ASBMB
Several different receptor proteins have been identified that bind monomeric, oligomeric, or
fibrillar forms of amyloid-β (Aβ)." Good" receptors internalize Aβ or promote its transcytosis …

CD36, a scavenger receptor implicated in atherosclerosis

YM Park - Experimental & molecular medicine, 2014 - nature.com
CD36 is a membrane glycoprotein that is present on various types of cells, including
monocytes, macrophages, microvascular endothelial cells, adipocytes and platelets …

CD36 in chronic kidney disease: novel insights and therapeutic opportunities

X Yang, DM Okamura, X Lu, Y Chen… - Nature Reviews …, 2017 - nature.com
CD36 (also known as scavenger receptor B2) is a multifunctional receptor that mediates the
binding and cellular uptake of long-chain fatty acids, oxidized lipids and phospholipids …

B cells and humoral immunity in atherosclerosis

D Tsiantoulas, CJ Diehl, JL Witztum… - Circulation research, 2014 - Am Heart Assoc
Insights into the important contribution of inflammation and immune functions in the
development and progression of atherosclerosis have greatly improved our understanding …