Scavenger receptors constitute a large family of proteins that are structurally diverse and
participate in a wide range of biological functions. These receptors are expressed …

Background Multicellular organisms have evolved systems/mechanisms to detect various
forms of danger, including attack by microbial pathogens and a variety of pests, as well as …

Particulate ligands, including cholesterol crystals and amyloid fibrils, induce production of
interleukin 1β (IL-1β) dependent on the cytoplasmic sensor NLRP3 in atherosclerosis …

The prevalence of obesity, insulin resistance and diabetes is increasing rapidly. Most
patients with these disorders have hypertriglyceridaemia and increased plasma levels of …

Scavenger receptors were originally identified by their ability to recognize and to remove
modified lipoproteins; however, it is now appreciated that they carry out a striking range of …

Coronary artery disease (CAD) arising from atherosclerosis is a leading cause of death and
morbidity worldwide. The underlying pathogenesis involves an imbalanced lipid metabolism …

Perturbations in lipid homeostasis combined with conditions favoring oxidative stress
constitute a hallmark of the inflammatory response. In this review we focus on the most …

Abstract Families of innate immune receptors serve as the bodies primary defence system
by recognising and rapidly responding to infection by microorganisms or to endogenous …

Triggering receptor expressed on myeloid cells 2 (TREM2) has been suggested to play a
crucial role in Alzheimer's disease (AD) pathogenesis, as revealed by genome-wide …

Microglial cells are the resident macrophages in the central nervous system. These cells of
mesodermal/mesenchymal origin migrate into all regions of the central nervous system …