Objective—Although the role of monocytes in the pathogenesis of atherosclerosis is well
established, the persistent vascular inflammation remains largely unexplained. Recently, our …

Ageing, infections and inflammation result in oxidative stress that can irreversibly damage
cellular structures. The oxidative damage of lipids in membranes or lipoproteins is one of …

Perturbations in lipid homeostasis combined with conditions favoring oxidative stress
constitute a hallmark of the inflammatory response. In this review we focus on the most …

Virtually all phases of spinal cord injury pathogenesis, including inflammation, cell
proliferation and differentiation, as well as tissue remodeling, are mediated in part by …

Inflammation contributes to many of the characteristics of plaques implicated in the
pathogenesis of acute coronary syndromes. Moreover, inflammatory pathways not only …

In atherosclerosis, the accumulation of apolipoprotein B-lipoproteins in the matrix beneath
the endothelial cell layer of blood vessels leads to the recruitment of monocytes, the cells of …

Despite the enormous progress in the understanding of the course of the ischemic stroke
over the last few decades, a therapy that effectively protects neurovascular units (NVUs) and …

Over the past several decades, much has been revealed about the nature of the host innate
immune response to microorganisms, with the identification of pattern recognition receptors …

The discovery of Toll-like receptors (TLRs) as components that recognize conserved
structures in pathogens has greatly advanced understanding of how the body senses …

Sensory neurons are activated by physical and chemical stimuli, eliciting sensations such as
temperature, touch, pain, and itch. From an evolutionary perspective, sensing danger is …