Intracerebral hemorrhage (ICH) accounts for 10–15% of all strokes and is associated with
high mortality and morbidity. Currently, no effective medical treatment is available to improve …

The inflammatory nature of atherosclerosis is well established but the agent (s) that incite
inflammation in the artery wall remain largely unknown. Germ-free animals are susceptible …

Toll-like receptors (TLRs) are recognition molecules for multiple pathogens, including
bacteria, viruses, fungi, and parasites. TLR2 forms heterodimers with TLR1 and TLR6, which …

The development and progression of hepatocellular carcinoma (HCC) are dependent on its
local microenvironment. Hypoxia and inflammation are two critical factors that shape the …

In 1907 Alois Alzheimer observed, as he quoted, development of “numerous fibers” and
“adipose saccules” in the brain of his diseased patient Auguste Deter. The …

Inflammation is associated with many neurodegenerative diseases, including Alzheimer's
disease, Parkinson's disease, amyotrophic lateral sclerosis, and multiple sclerosis. In this …

Alzheimer's disease (AD) is the most common cause of dementia in the elderly. Although its
pathogenesis remains unclear, studies have indicated microglia-mediated …

Inflammation and lipid signaling are intertwined modulators of homeostasis and immunity. In
addition to the extensively studied eicosanoids and inositol phospholipids, emerging studies …

Alzheimer's disease (AD) is a devastating condition with no known effective treatment. AD is
characterized by memory loss as well as impaired locomotor ability, reasoning, and …

Alzheimer's disease (AD) is a debilitating neurological disorder, and currently, there is no
cure for it. Several pathologic alterations have been described in the brain of AD patients …