Sodium homeostasis in the tumour microenvironment

TK Leslie, AD James, F Zaccagna, JT Grist… - … et Biophysica Acta (BBA …, 2019 - Elsevier
The concentration of sodium ions (Na+) is raised in solid tumours and can be measured at
the cellular, tissue and patient levels. At the cellular level, the Na+ gradient across the …

[HTML][HTML] The interplay of dysregulated pH and electrolyte imbalance in cancer

KO Alfarouk, SBM Ahmed, A Ahmed, RL Elliott… - Cancers, 2020 - mdpi.com
Cancer cells and tissues have an aberrant regulation of hydrogen ion dynamics driven by a
combination of poor vascular perfusion, regional hypoxia, and increased the flux of carbons …

[HTML][HTML] Control of Ca2+ and metabolic homeostasis by the Na+/Ca2+ exchangers (NCXs) in health and disease

T Rodrigues, S Piccirillo, S Magi, A Preziuso… - Biochemical …, 2022 - Elsevier
Spatial and temporal control of calcium (Ca 2+) levels is essential for the background
rhythms and responses of living cells to environmental stimuli. Whatever other regulators a …

[HTML][HTML] Advances in intracellular calcium signaling reveal untapped targets for cancer therapy

A Sharma, GT Ramena, RC Elble - Biomedicines, 2021 - mdpi.com
Intracellular Ca2+ distribution is a tightly regulated process. Numerous Ca2+ chelating,
storage, and transport mechanisms are required to maintain normal cellular physiology …

Studies on cerebral protection of digoxin against ischemia/reperfusion injury in mice

S Kaur, AK Rehni, N Singh, AS Jaggi - Yakugaku Zasshi, 2009 - jstage.jst.go.jp
The present study was designed to investigate the possible neuroprotective eŠect of digoxin
induced pharmacological preconditioning (PP) and its probable mechanism. Bilateral …

Emerging Roles of Sodium/Calcium Exchangers in Cancer

T Rodrigues, VS Ramos, LFL do Prado-Souza… - Handbook of Cancer …, 2024 - Springer
Cancer is a group of neoplastic diseases that shares as common feature uncontrolled
cellular proliferation. Tumorigenesis and cancer progression are mediated by genetic …

[PDF][PDF] Advances in Intracellular Calcium Signaling Reveal Untapped Targets for Cancer Therapy. Biomedicines 2021, 9, 1077

A Sharma, GT Ramena, RC Elble - 2021 - academia.edu
Intracellular Ca2+ distribution is a tightly regulated process. Numerous Ca2+ chelating,
storage, and transport mechanisms are required to maintain normal cellular physiology …

Synthesis of Highly Substituted Pyrrolidines Through 1,3-Dipolar Cycloaddition Reaction of N-Metalated Azomethine Ylides with Triarylideneacetylacetone as …

R Murugan, R Raghunathan… - Synthetic …, 2009 - Taylor & Francis
Abstract The 1, 3-dipolar cycloaddition reaction of tryarylideneacetyacetone derivatives with
N-metalated azomethine ylides in the presence of titanocene dichloride and triethylamine …

Daunorubicin and doxorubicin inhibit the [11C] choline accumulation in cancer cells

P Mikecz, T Márián, T Miklovicz, L Galuska… - Applied Radiation and …, 2009 - Elsevier
We studied how very short (10–40min) incubation with anthracycline derivatives modifies
the accumulation of PET tumor-diagnostic radiotracers in cancer cells. The human ovarian …