Brain iron homeostasis is maintained through the normal function of blood–brain barrier and
iron regulation at the systemic and cellular levels, which is fundamental to normal brain …

Abstract Iron-sulfur (Fe-S) clusters are involved in fundamental biological reactions and
represent a highly regulated process involving a complex sequence of mitochondrial …

Understanding the basis for cellular growth, proliferation, and function requires determining
the roles of essential genes in diverse cellular processes, including visualizing their …

Bacterial biofilm-associated infection has been one of the largest threats to global public
health due to serious antibiotic resistance. It is urgently needed to develop new bactericides …

Target identification remains a critical challenge in inorganic drug discovery to deconvolute
potential polypharmacology. Herein, we describe an improved approach to prioritize …

Neurodegeneration is characterized by a disturbance in neurotransmitter-mediated
signaling pathways. Recent studies have highlighted the significant role of transition metal …

The tumor microenvironment (TME) promotes the malignant transformation of cancer cells,
mainly through metabolic reprogramming. As one of the most prominent features of the TME …

Fluctuations in nutrient and biomass availability, often as a result of disease, impart
metabolic challenges that must be overcome in order to sustain cell survival and promote …

In a phenotypical screen of 56 acute myeloid leukemia (AML) patient samples and using a
library of 10,000 compounds, we identified a hit with increased sensitivity toward SF3B1 …

Friedreich's ataxia (FRDA) is the most prevalent autosomic recessive ataxia and is
associated with a severe cardiac hypertrophy and less frequently diabetes. It is caused by …