The joint analysis of the genome, epigenome, transcriptome, proteome and/or metabolome
from single cells is transforming our understanding of cell biology in health and disease. In …

Cell type-specific gene expression patterns and dynamics during development or in disease
are controlled by cis-regulatory elements (CREs), such as promoters and enhancers …

The primary motor cortex (M1) is essential for voluntary fine-motor control and is functionally
conserved across mammals. Here, using high-throughput transcriptomic and epigenomic …

Understanding kidney disease relies on defining the complexity of cell types and states, their
associated molecular profiles and interactions within tissue neighbourhoods. Here we …

In situ transcriptomic techniques promise a holistic view of tissue organization and cell-cell
interactions. There has been a surge of multiplexed RNA in situ mapping techniques but …

Dynamically organized chromatin complexes often involve multiplex chromatin interactions
and sometimes chromatin-associated RNA,–. Chromatin complex compositions change …

Droplet microfluidic technology has revolutionized biomolecular analytical research, as it
has the capability to reserve the genotype-to-phenotype linkage and assist for revealing the …

With the rapid advance of single-cell sequencing technology, cell heterogeneity in various
biological processes was dissected at different omics levels. However, single-cell mono …

Background Previous studies have traditionally attributed the initiation of cancer cells to
genetic mutations, considering them as the fundamental drivers of carcinogenesis. However …

Microglia, the major population of brain‐resident macrophages, are now recognized as a
heterogeneous population comprising several cell subtypes with different (so far mostly …