Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

Saponins represent important natural derivatives of plant triterpenoids that are secondary
plant metabolites. Saponins, also named glycoconjugates, are available both as natural and …

Several plant-derived natural products with anti-SARS-CoV-2 activity have been evaluated
for the potential to serve as chemotherapeutic agents for the treatment of COVID-19 …

The fusion of viral and cell membranes is one of the basic processes in the life cycles of
viruses. A number of enveloped viruses confer fusion of the viral envelope and the cell …

In order to test the antiviral activity, a series of usnic acid derivatives were synthesized,
including new, previously undescribed compounds. The activity of the derivatives against …

The recent global Omicron epidemics underscore the great need for the development of
small molecule therapeutics with appropriate mechanisms. The trimeric spike protein (S) of …

Artemisia argyi H. Lév. & Vaniot (A. argyi), a traditional Chinese herbal medicine, has been
commonly used in plague epidemics and has bactericidal and sterilizing pharmacological …

Previous studies indicated that natural-based chalcones have significant inhibitory effects on
the coronavirus enzymes 3CLpro and PLpro as well as modulation of some host-based …

SARS-CoV-2 Omicron viruses possess a high antigenic shift, and the approved anti-SARS-
CoV-2 drugs are extremely limited, which makes the development of new antiviral drugs for …

Since the beginning of the COVID-19 pandemic, extensive drug repurposing efforts have
sought to identify small-molecule antivirals with various mechanisms of action. Here, we aim …