Type 2 diabetes (T2D) had long been referred to as the" geneticist's nightmare." Genome-
wide association studies have fully confirmed the polygenic nature of T2D, demonstrating …

Genome-wide association studies (GWAS) have facilitated a substantial and rapid rise in the
number of confirmed genetic susceptibility variants for type 2 diabetes (T2D). Approximately …

OBJECTIVE Glycated hemoglobin (HbA1c), used to monitor and diagnose diabetes, is
influenced by average glycemia over a 2-to 3-month period. Genetic factors affecting …

Chronic infection with the hepatitis C virus (HCV) affects 170 million people worldwide and
is an important cause of liver-related morbidity and mortality. The standard of care therapy …

The elucidation of several genetic etiologies of both monogenic and polygenic type 2
diabetes (T2D) has revealed several key regulators of glucose homeostasis and insulin …

OBJECTIVE Glycemia is a major risk factor for the development of long-term complications
in type 1 diabetes; however, no specific genetic loci have been identified for glycemic control …

Abstract Background/Aims: In a family with congenital hyperinsulinism (HI), first described in
the 1950s by McQuarrie, we examined the genetic locus and clinical phenotype of a novel …

Blood cells participate in vital physiological processes, and their numbers are tightly
regulated so that homeostasis is maintained. Disruption of key regulatory mechanisms …

Abstract Hexokinase 1 (HK1) and pyruvate kinase M2 (PKM2) are two key regulators in
glycosis and oncogenic markers in cancers. In the present study, we investigated the …

Abstract Objectives Glycated haemoglobin (HbA1c) is associated with cardiovascular
disease risk in individuals without diabetes, and its use has been recommended for …