Individual genetic variability mainly of Proinflammatory cytokines, cytokine receptors, and toll‐like receptors dictates pathophysiology of COVID‐19 disease

MK Vakil, Y Mansoori, GRL Al‐Awsi… - Journal of Medical …, 2022 - Wiley Online Library
Innate and acquired immunity responses are crucial for viral infection elimination. However,
genetic variations in coding genes may exacerbate the inflammation or initiate devastating …

Diabetes as one of the long-term COVID-19 complications: from the potential reason of more diabetic patients' susceptibility to COVID-19 to the possible caution of …

Y Sharbatdar, R Mousavian… - …, 2023 - Springer
According to recent researches, people with diabetes mellitus (type 1 and 2) have a higher
incidence of coronavirus disease 2019 (COVID-19), which is caused by a SARS-CoV-2 …

Single nucleotide polymorphisms located in TNFA, IL1RN, IL6R, and IL6 genes are associated with COVID‐19 risk and severity in an Iranian population

M Rokni, M Sarhadi, M Heidari Nia… - Cell Biology …, 2022 - Wiley Online Library
Cytokines play pivotal functions in coronavirus disease 2019 (COVID‐19) pathogenesis.
However, little is known about the rationale and importance of genetic variations associated …

Implications of the Immune Polymorphisms of the Host and the Genetic Variability of SARS-CoV-2 in the Development of COVID-19

J Zepeda-Cervantes, D Martínez-Flores… - Viruses, 2022 - mdpi.com
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for the
current pandemic affecting almost all countries in the world. SARS-CoV-2 is the agent …

[HTML][HTML] Effects of selected inherited factors on susceptibility to SARS-CoV-2 infection and COVID-19 progression

JA Hubacek - Physiological Research, 2021 - ncbi.nlm.nih.gov
Genetic predispositions may influence geographical and interethnic differences in COVID-
19 prevalence and mortality in affected populations. Of the many genes implicated in COVID …

Impact of IL-6 rs1800795 and IL-17A rs2275913 gene polymorphisms on the COVID-19 prognosis and susceptibility in a sample of Iranian patients

M Khafaei, R Asghari, F Zafari, M Sadeghi - Cytokine, 2024 - Elsevier
Background From asymptomatic to acute and life-threatening pulmonary infection, the
clinical manifestations of COVID-19 are highly variable. Interleukin (IL)-6 and IL-17A are key …

Timeline kinetics of systemic and airway immune mediator storm for comprehensive analysis of disease outcome in critically ill COVID-19 patients

JJ Goncalves, CPSM da Mata, AA Lourenco… - Frontiers in …, 2022 - frontiersin.org
In the present study, the levels of serum and airway soluble chemokines, pro-inflammatory/
regulatory cytokines, and growth factors were quantified in critically ill COVID-19 patients …

Single-Cell Gene Expression Analysis Revealed Immune Cell Signatures of Delta COVID-19

AM Shaymardanov, OA Antonova, AD Sokol… - Cells, 2022 - mdpi.com
The coronavirus disease 2019 (COVID-19) is accompanied by a cytokine storm with the
release of many proinflammatory factors and development of respiratory syndrome. Several …

Association of inhibitory NKG2A and activating NKG2D natural killer cell receptor genes with resistance to SARS-CoV-2 infection in a western Indian population

AS Tripathy, P Wagh, K Akolkar, AM Walimbe… - Archives of …, 2023 - Springer
We have evaluated the association of polymorphisms in the intronic variable-number
tandem repeat (VNTR) regions of the human NKG2D, NKG2A, and IL-1RN genes with …

[PDF][PDF] Polimorfismo da ACE2 ea Influência na Suscetibilidade frente à COVID-19

MR Reser - Brazilian Journal of Development, 2021 - scholar.archive.org
RESUMO COVID-19 é a doença infecciosa causada pelo coronavírus descoberto mais
recentemente, o SARS-CoV-2. O vírus liga-se aos receptores da enzima conversora de …