The incidence and mortality rate of cancer has been quickly increasing in the past decades.
At present, cancer has become the leading cause of death worldwide. Most of the cancers …

Abstract Phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR)
signaling is one of the most important intracellular pathways, which can be considered as a …

Therapeutic effectiveness in breast cancer can be limited by the underlying mechanisms of
pathogenesis, including epithelial-mesenchymal transition (EMT), cancer stem cells (CSCs) …

Breast cancer is the most common cancer, and the second cause of cancer-related deaths
(after lung cancer) among women. Developing tumor metastasis and invasion is the most …

Triple-negative breast cancer (TNBC) is currently the most malignant subtype of breast
cancer without effective targeted therapies, which makes its pathogenesis an important …

Long non-coding RNAs (lncRNAs) are associated with human diseases. Although lncRNA–
disease associations have received significant attention, no online repository is available to …

Breast cancer (BC) as one of the most common causes of human deaths among women, is
always considered one of the global health challenges. Despite various advances in …

Altered energy metabolism is one of the hallmarks of tumorigenesis and essential for
fulfilling the high demand for metabolic energy in a tumor through accelerating glycolysis …

The cellular signaling network involves co-ordinated regulation of numerous signaling
molecules that aid the maintenance of cellular as well as organismal homeostasis. Aberrant …

Long noncoding RNAs (lncRNAs) have been identified as contributors to the development
and progression of cancer through various functions and mechanisms. LncRNA GAS5 is …