The genetic architecture of human reproductive behavior—age at first birth (AFB) and
number of children ever born (NEB)—has a strong relationship with fitness, human …

Menopause is a signal event in a woman's life that marks the end of reproductive
competence. Although the age-related loss of vaginal bleeding in women has been …

Oocyte aging has a significant impact on reproductive outcomes both quantitatively and
qualitatively. However, the molecular mechanisms underlying the age-related decline in …

Summary Background Primary Ovarian Insufficiency (POI), a public health problem, affects 1-
3.7% of women under 40 yielding infertility and a shorter lifespan. Most causes are …

Premature ovarian failure (POF) is a common cause of infertility in women, characterized by
amenorrhea, hypoestrogenism, and elevated gonadotropin levels in women under the age …

BACKGROUND Oocyte number is established early in life before a gradual loss of this
ovarian reserve during reproductive life until oocyte availability becomes limiting at the …

Age at menarche (AAM) is an important marker of the pubertal development and function of
the hypothalamic–pituitary–ovarian system. It was reported as a possible factor for a risk of …

Spontaneous dizygotic (DZ) twinning occurs in 1%–4% of women, with familial clustering
and unknown physiological pathways and genetic origin. DZ twinning might index increased …

Purpose Early menopause (EM, age at menopause< 45 years) and premature ovarian
insufficiency (POI, age at menopause< 40 years) are associated with an increased risk of …

Introduction: Polycystic ovary syndrome (PCOS) is a hormonal and metabolic disorder
affecting 5 to 20% of reproductive-aged women worldwide that results in androgen excess …