Prediction models for diagnosis and prognosis of covid-19: systematic review and critical appraisal

L Wynants, B Van Calster, GS Collins, RD Riley… - bmj, 2020 - bmj.com
Objective To review and appraise the validity and usefulness of published and preprint
reports of prediction models for prognosis of patients with covid-19, and for detecting people …

Charlson comorbidity index and a composite of poor outcomes in COVID-19 patients: A systematic review and meta-analysis

RAT Kuswardhani, J Henrina, R Pranata… - Diabetes & Metabolic …, 2020 - Elsevier
Background and aims The ongoing COVID-19 pandemic is disproportionately affecting
patients with comorbidities. Therefore, thorough comorbidities assessment can help …

[HTML][HTML] Interleukin-6 is a biomarker for the development of fatal severe acute respiratory syndrome coronavirus 2 pneumonia

A Santa Cruz, A Mendes-Frias, AI Oliveira… - Frontiers in …, 2021 - frontiersin.org
Hyper-inflammatory responses induced by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) are a major cause of disease severity and death. Predictive prognosis …

[HTML][HTML] An immune-based biomarker signature is associated with mortality in COVID-19 patients

MS Abers, OM Delmonte, EE Ricotta, J Fintzi, DL Fink… - JCI insight, 2021 - ncbi.nlm.nih.gov
Immune and inflammatory responses to severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) contribute to disease severity of coronavirus disease 2019 (COVID-19) …

[HTML][HTML] The central role of the nasal microenvironment in the transmission, modulation, and clinical progression of SARS-CoV-2 infection

O Gallo, LG Locatello, A Mazzoni, L Novelli… - Mucosal …, 2021 - Elsevier
The novel coronavirus SARS-CoV-2 enters into the human body mainly through the ACE2+
TMPRSS2+ nasal epithelial cells. The initial host response to this pathogen occurs in a …

IL-6 and other biomarkers as predictors of severity in COVID-19

N Broman, K Rantasärkkä, T Feuth, M Valtonen… - Annals of …, 2021 - Taylor & Francis
Objective Cytokine release syndrome is suggested to be the most important mechanism
triggering acute respiratory distress syndrome and end organ damage in COVID-19. The …

Severe COVID-19: a multifaceted viral vasculopathy syndrome

CM Magro, J Mulvey, J Kubiak, S Mikhail… - Annals of diagnostic …, 2021 - Elsevier
The objective of this study was to elucidate the pathophysiology that underlies severe
COVID-19 by assessing the histopathology and the in situ detection of infectious SARS-CoV …

[HTML][HTML] Metabolomic/lipidomic profiling of COVID-19 and individual response to tocilizumab

G Meoni, V Ghini, L Maggi, A Vignoli, A Mazzoni… - PLoS …, 2021 - journals.plos.org
The current pandemic emergence of novel coronavirus disease (COVID-19) poses a
relevant threat to global health. SARS-CoV-2 infection is characterized by a wide range of …

[HTML][HTML] Thromboinflammatory biomarkers in COVID-19: systematic review and meta-analysis of 17,052 patients

R Chaudhary, J Garg, DE Houghton, MH Murad… - … : Innovations, Quality & …, 2021 - Elsevier
Objective To evaluate differences in thromboinflammatory biomarkers between patients with
severe coronavirus disease 2019 (COVID-19) infection/death and mild infection. Patients …

Hallmarks of immune response in COVID-19: Exploring dysregulation and exhaustion

A Mazzoni, L Salvati, L Maggi, F Annunziato… - Seminars in …, 2021 - Elsevier
One and half year following the occurrence of COVID-19 pandemic, significant efforts from
laboratories all over the world generated a huge amount of data describing the prototypical …