Depression rates in young people have risen sharply in the past decade, especially in
females, which is of concern because adolescence is a period of rapid social, emotional …

Background Misconceptions about ADHD stigmatize affected people, reduce credibility of
providers, and prevent/delay treatment. To challenge misconceptions, we curated findings …

Traditional diagnostic systems went beyond empirical evidence on the structure of mental
health. Consequently, these diagnoses do not depict psychopathology accurately, and their …

Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-
wide association study of 41,917 bipolar disorder cases and 371,549 controls of European …

Behaviors and disorders related to self-regulation, such as substance use, antisocial
behavior and attention-deficit/hyperactivity disorder, are collectively referred to as …

Importance Autism spectrum disorder (ASD), characterized by deficits in social
communication and the presence of restricted, repetitive behaviors or interests, is a …

It is unclear whether transgender and gender-diverse individuals have elevated rates of
autism diagnosis or traits related to autism compared to cisgender individuals in large non …

Recent studies proposed a general psychopathology factor underlying common
comorbidities among psychiatric disorders. However, its neurobiological mechanisms and …

Practitioners frequently use diagnostic criteria to identify children with neurodevelopmental
disorders and to guide intervention decisions. These criteria also provide the organising …

The synaptic hypothesis of schizophrenia has been highly influential. However, new
approaches mean there has been a step-change in the evidence available, and some tenets …