Psychiatric disorders present distinct clinical challenges which are partly attributable to their
multifactorial aetiology and the absence of laboratory tests that can be used to confirm …

Abstract Study Objectives We aimed to detect cross-sectional phenotype and polygenic risk
score (PRS) associations between sleep duration and prevalent diseases using the Partners …

There are currently no reliable approaches for correctly identifying which patients with major
depressive disorder (MDD) will respond well to antidepressant therapy. However, recent …

Genetic risk prediction is an important problem in human genetics, and accurate prediction
can facilitate disease prevention and treatment. Calculating polygenic risk score (PRS) has …

Variation in reproductive lifespan and female fertility have implications for health, population
size and ageing. Fertility declines well before general signs of menopause and is also …

Sepsis is a series of clinical syndromes caused by the immunological response to infection.
The clinical evidence for sepsis could typically attribute to bacterial infection or bacterial …

BackgroundHospital-based biobanks are being increasingly considered as a resource for
translating polygenic risk scores (PRS) into clinical practice. However, since these biobanks …

Objective To assess whether the polygenic risk score (PRS) for migraine is associated with
acute and/or prophylactic migraine treatment response. Methods We interviewed 2,219 …

Background Genome‐wide association studies (GWAS) have identified thousands of
susceptibility variants, although most have been associated with small individual risk …

Abstract Treatment-resistant depression (TRD) occurs in~ 30% of patients with major
depressive disorder (MDD) but the genetics of TRD was previously poorly investigated …