Genetic analyses implicate complex links between adult testosterone levels and health and disease
JT Leinonen, N Mars, LE Lehtonen… - Communications …, 2023 - nature.com
Background Testosterone levels are linked with diverse characteristics of human health, yet,
whether these associations reflect correlation or causation remains debated. Here, we …
whether these associations reflect correlation or causation remains debated. Here, we …
Sibling variation in polygenic traits and DNA recombination mapping with UK Biobank and IVF family data
We use UK Biobank and a unique IVF family dataset (including genotyped embryos) to
investigate sibling variation in both phenotype and genotype. We compare phenotype …
investigate sibling variation in both phenotype and genotype. We compare phenotype …
Use of multiple polygenic risk scores for distinguishing schizophrenia-spectrum disorder and affective psychosis categories in a first-episode sample; the EU-GEI study
V Rodriguez, L Alameda, D Quattrone… - Psychological …, 2023 - cambridge.org
Background Schizophrenia (SZ), bipolar disorder (BD) and depression (D) run in families.
This susceptibility is partly due to hundreds or thousands of common genetic variants, each …
This susceptibility is partly due to hundreds or thousands of common genetic variants, each …
[HTML][HTML] A Wolf in Sheep's Clothing: Idealisations and the aims of polygenic scores
D Serpico - Studies in History and Philosophy of Science, 2023 - Elsevier
Research in pharmacogenomics and precision medicine has recently introduced the
concept of Polygenic Scores (PGSs), namely, indexes that aggregate the effects that many …
concept of Polygenic Scores (PGSs), namely, indexes that aggregate the effects that many …
Insights into respiratory disease through bioinformatics
Respiratory diseases such as asthma, chronic obstructive pulmonary disease and lung
cancer represent a critical area for medical research as millions of people are affected …
cancer represent a critical area for medical research as millions of people are affected …
Associations between polygenic risk for tobacco and alcohol use and liability to tobacco and alcohol use, and psychiatric disorders in an independent sample of …
Background Substance use, substance use disorders (SUDs), and psychiatric disorders
commonly co-occur. Genetic risk common to these complex traits is an important …
commonly co-occur. Genetic risk common to these complex traits is an important …
Selecting variants of unknown significance through network-based gene-association significantly improves risk prediction for disease-control cohorts
Variants of unknown/uncertain significance (VUS) pose a huge dilemma in current genetic
variation screening methods and genetic counselling. Driven by methods of next generation …
variation screening methods and genetic counselling. Driven by methods of next generation …
A polygenic approach to understanding resilience to peer victimisation
Previous studies suggest an individual's risk of depression following adversity may be
moderated by their genetic liability. No study, however, has examined peer victimisation, an …
moderated by their genetic liability. No study, however, has examined peer victimisation, an …
Polygenic risk scores in prostate cancer risk assessment and screening
L Byrne, AE Toland - Urologic Clinics, 2021 - urologic.theclinics.com
Prostate cancer (PCa) is the most common cancer among men with a lifetime risk of 12%
and median age of diagnosis of 66. 1 In 2020, 191,930 new cases are expected to be …
and median age of diagnosis of 66. 1 In 2020, 191,930 new cases are expected to be …
Evaluating marginal genetic correlation of associated loci for complex diseases and traits between European and East Asian populations
Genome-wide association studies (GWASs) have successfully identified a large amount of
single-nucleotide polymorphisms associated with many complex phenotypes in diverse …
single-nucleotide polymorphisms associated with many complex phenotypes in diverse …