Background: Breast cancer (BC) screening with mammography reduces mortality but
considers currently only age as a risk factor. Personalized risk-based screening has been …

Electronic health records (EHR) offer unprecedented opportunities for in-depth clinical
phenotyping and prediction of clinical outcomes. Combining multiple data sources is crucial …

Machine learning methods applied to large genomic datasets (such as those used in GWAS)
have led to the creation of polygenic risk scores (PRSs) that can be used identify individuals …

Considering the relatively high heritability of schizophrenia and the fact that it significantly
reduces the reproductive fitness of affected individuals, it is not clear how the disorder is still …

Research has shown that therapeutic sleep deprivation (SD) has rapid antidepressant
effects in the majority of depressed patients. Investigation of factors preceding and …

Recent studies suggest that the endocannabinoid system could play an important role in the
physiopathology of obsessive-compulsive disorder (OCD). There are reports of effective …

Background Hypertensive disorders during pregnancy are associated with the risk of long-
term cardiovascular disease after pregnancy, but it has not yet been determined whether …

Background Depression has been linked to an increased risk of cardiovascular and
respiratory diseases; however, its impact on cardiac and lung function remains unclear …

Antipsychotic-induced weight gain (AIWG) is a common adverse event in schizophrenia.
Genome-wide association studies (GWAS) and polygenic risk scores (PRS) for other …

Genome‐wide association studies have revolutionized our understanding of the genetic
architecture of complex traits and diseases over the last decade. This knowledge is enabling …