Moisturizer is a major component of basic daily skin care, particularly in presence of
epidermal barrier alteration and reduced epidermal water content. It is an important part of a …

Palmitoylethanolamide (PEA) has emerged as a potential nutraceutical, because this
compound is naturally produced in many plant and animal food sources, as well as in cells …

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription
factors of nuclear hormone receptor superfamily comprising of the following three subtypes …

All nations which have undergone a nutrition transition have experienced increased
frequency and falling latency of chronic degenerative diseases, which are largely driven by …

Palmitoylethanolamide (PEA, N-hexadecanoylethanolamide) is an endogenous compound
belonging to the family of N-acylethanolamines. PEA has anti-inflammatory and analgesic …

Preparations of the Cannabis sativa plant have been used to analgesic effect for millenia,
but only in recent decades has the endogenous system responsible for these effects been …

Glia and microglia in particular elaborate pro‐inflammatory molecules that play key roles in
central nervous system (CNS) disorders from neuropathic pain and epilepsy to …

Objective Enteric glia activation has been reported to amplify intestinal inflammation via the
enteroglial-specific S100B protein. This neurotrophin promotes macrophage recruitment in …

Primary sensory afferents and their neighboring host-defense cells are a rich source of lipid-
derived mediators that contribute to the sensation of pain caused by tissue damage and …

One of the more important recent advances in neuroscience research is the understanding
that there is extensive communication between the immune system and the central nervous …