Phenoconversion is the mismatch between the individual's genotype-based prediction of
drug metabolism and the true capacity to metabolize drugs due to nongenetic factors. While …

Fucoxanthin is a marine carotenoid exhibiting several health benefits. The anti-cancer effect
of fucoxanthin and its deacetylated metabolite, fucoxanthinol, is well documented. In view of …

Abstract The European Commission asked EFSA to update their 2006 opinion on ochratoxin
A (OTA) in food. OTA is produced by fungi of the genus Aspergillus and Penicillium and …

EFSA was asked to deliver a scientific opinion on the risks to public health related to the
presence of aflatoxins in food. The risk assessment was confined to aflatoxin B1 (AFB 1) …

Pharmacogenomics is a key component of personalized medicine that promises safer and
more effective drug treatment by individualizing drug choice and dose based on genetic …

Abstract The cytochrome P450 (P450) enzymes first attracted interest because of their
relevance to the metabolism of drugs, steroids, and carcinogens. Collectively, the 57 human …

Genetic variation can affect drug response in multiple ways, although it remains unclear how
rare genetic variants affect drug response. The electronic Medical Records and Genomics …

Pyrrolizidine alkaloids (PAs) are natural toxins widely distributed in plants. The toxic
potencies of different PAs vary significantly. PAs are mono-or diesters of necine acids with a …

Abstract Purpose Tacrolimus (Tac) and cyclosporine (CsA) are mainly metabolized by
CYP3A4 and CYP3A5. Several studies have demonstrated an association between the …

There are conflicting results about sex differences in the response to opioids for pain control
and the role of potential influencing factors of these differences has not been investigated …