MUC16 (CA125): tumor biomarker to cancer therapy, a work in progress

M Felder, A Kapur, J Gonzalez-Bosquet, S Horibata… - Molecular cancer, 2014 - Springer
Over three decades have passed since the first report on the expression of CA125 by
ovarian tumors. Since that time our understanding of ovarian cancer biology has changed …

Mucins: Structural diversity, biosynthesis, its role in pathogenesis and as possible therapeutic targets

SS Dhanisha, C Guruvayoorappan, S Drishya… - Critical reviews in …, 2018 - Elsevier
Mucins are the main structural components of mucus that create a selective protective
barrier for epithelial surface and also execute wide range of other physiological functions …

Ocular surface membrane-associated mucins

AF Ablamowicz, JJ Nichols - The ocular surface, 2016 - Elsevier
Ocular surface epithelial cells produce and secrete mucins that form a hydrophilic barrier for
protection and lubrication of the eye. This barrier, the glycocalyx, is formed by high …

Mucin glycoproteins block apoptosis; promote invasion, proliferation, and migration; and cause chemoresistance through diverse pathways in epithelial cancers

IS Reynolds, M Fichtner, DA McNamara… - Cancer and Metastasis …, 2019 - Springer
Overexpression of mucin glycoproteins has been demonstrated in many epithelial-derived
cancers. The significance of this overexpression remains uncertain. The aim of this paper …

The promise of protein glycosylation for personalised medicine

A Almeida, D Kolarich - Biochimica et Biophysica Acta (BBA)-General …, 2016 - Elsevier
Background Complex diseases such as cancer are a consequence of numerous causes.
State of the art personalised medicine approaches are mostly based on evaluating patients' …

Cell adhesion molecules in plasticity and metastasis

JA Smart, JE Oleksak, EJ Hartsough - Molecular Cancer Research, 2021 - AACR
Prior to metastasis, modern therapeutics and surgical intervention can provide a favorable
long-term survival for patients diagnosed with many types of cancers. However, prognosis is …

MUC1: the first respiratory mucin with an anti-inflammatory function

K Kato, EP Lillehoj, W Lu, KC Kim - Journal of clinical medicine, 2017 - mdpi.com
MUC1 is a membrane-bound mucin expressed on the apical surfaces of most mucosal
epithelial cells. In normal lung epithelia, MUC1 is a binding site for Pseudomonas …

The role of mucin 1 in respiratory diseases

B Ballester, J Milara, J Cortijo - European Respiratory Review, 2021 - Eur Respiratory Soc
Recent evidence has demonstrated that mucin 1 (MUC1) is involved in many pathological
processes that occur in the lung. MUC1 is a transmembrane protein mainly expressed by …

[HTML][HTML] Mucin in cancer: a stealth cloak for cancer cells

DH Wi, JH Cha, YS Jung - BMB reports, 2021 - ncbi.nlm.nih.gov
Mucins are high molecular-weight epithelial glycoproteins and are implicated in many
physiological processes, including epithelial cell protection, signaling transduction, and …

[HTML][HTML] The genomic landscape of fibrolamellar hepatocellular carcinoma: whole genome sequencing of ten patients

DG Darcy, R Chiaroni-Clarke, JM Murphy… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Fibrolamellar hepatocellular carcinoma is a rare, malignant liver tumor that often arises in
the otherwise normal liver of adolescents and young adults. Previous studies have focused …