Stent thrombosis and restenosis: what have we learned and where are we going? The Andreas Grüntzig Lecture ESC 2014

RA Byrne, M Joner, A Kastrati - European heart journal, 2015 - academic.oup.com
Modern-day stenting procedures leverage advances in pharmacotherapy and device
innovation. Patients treated with contemporary antiplatelet agents, peri-procedural …

Diabetes and restenosis

S Wilson, P Mone, U Kansakar, SS Jankauskas… - Cardiovascular …, 2022 - Springer
Restenosis, defined as the re-narrowing of an arterial lumen after revascularization,
represents an increasingly important issue in clinical practice. Indeed, as the number of stent …

In-stent restenosis in the drug-eluting stent era

GD Dangas, BE Claessen, A Caixeta… - Journal of the American …, 2010 - jacc.org
The introduction of the drug-eluting stent (DES) proved to be an important step forward in
reducing rates of restenosis and target lesion revascularization after percutaneous coronary …

Vascular inflammation and repair: implications for re-endothelialization, restenosis, and stent thrombosis

T Inoue, K Croce, T Morooka, M Sakuma… - JACC: Cardiovascular …, 2011 - jacc.org
The cellular and molecular processes that control vascular injury responses after
percutaneous coronary intervention involve a complex interplay among vascular cells and …

Drug-coated balloon angioplasty versus drug-eluting stent implantation in patients with coronary stent restenosis

D Giacoppo, F Alfonso, B Xu, BEPM Claessen… - Journal of the American …, 2020 - jacc.org
Background In patients with coronary in-stent restenosis (ISR) requiring reintervention, it is
unclear if the choice of treatment should depend on whether the restenotic stent was a bare …

Vascular smooth muscle cell proliferation in restenosis

SO Marx, H Totary-Jain, AR Marks - Circulation: Cardiovascular …, 2011 - Am Heart Assoc
Current therapeutic approaches to restore blood flow in stenotic blood vessels involve the
use of percutaneous devices and coronary bypass surgery. In all procedures that disrupt the …

[HTML][HTML] FGF regulates TGF-β signaling and endothelial-to-mesenchymal transition via control of let-7 miRNA expression

PY Chen, L Qin, C Barnes, K Charisse, T Yi, X Zhang… - Cell reports, 2012 - cell.com
Maintenance of normal endothelial function is critical to various aspects of blood vessel
function, but its regulation is poorly understood. In this study, we show that disruption of …

Mechanisms of drug-eluting stent restenosis

J Aoki, K Tanabe - Cardiovascular intervention and therapeutics, 2021 - Springer
Drug-eluting stents (DES) were developed to overcome in-stent restenosis (ISR), which has
long been considered the main complication limiting the long-term efficacy of coronary …

Multifunctional Pluronic P123/F127 mixed polymeric micelles loaded with paclitaxel for the treatment of multidrug resistant tumors

W Zhang, Y Shi, Y Chen, J Ye, X Sha, X Fang - Biomaterials, 2011 - Elsevier
The aim of this study was to exploit the possibility of combination of active targeting function
of folic acid by folate receptor-mediated endocytosis and overcoming multidrug resistance …

Drug-coated balloon therapy in coronary and peripheral artery disease

RA Byrne, M Joner, F Alfonso, A Kastrati - Nature Reviews Cardiology, 2014 - nature.com
Nonstent-based local drug delivery during percutaneous intervention offers potential for
sustained antirestenotic efficacy without the limitations of permanent vascular implants …