S Gerstberger, Q Jiang, K Ganesh - Cell, 2023 - cell.com
Most cancer-associated deaths occur due to metastasis, yet our understanding of metastasis as an evolving, heterogeneous, systemic disease and of how to effectively treat it is still …
Y Han, Y Wang, X Dong, D Sun, Z Liu… - Nucleic acids …, 2023 - academic.oup.com
Abstract The Tumor Immune Single Cell Hub 2 (TISCH2) is a resource of single-cell RNA- seq (scRNA-seq) data from human and mouse tumors, which enables comprehensive …
B Van de Sande, JS Lee, E Mutasa-Gottgens… - Nature Reviews Drug …, 2023 - nature.com
Single-cell technologies, particularly single-cell RNA sequencing (scRNA-seq) methods, together with associated computational tools and the growing availability of public data …
Deciphering the principles and mechanisms by which gene activity orchestrates complex cellular arrangements in multicellular organisms has far-reaching implications for research …
Single-cell atlases promise to provide a 'missing link'between genes, diseases and therapies. By identifying the specific cell types, states, programs and contexts where disease …
WR Becker, SA Nevins, DC Chen, R Chiu… - Nature …, 2022 - nature.com
To chart cell composition and cell state changes that occur during the transformation of healthy colon to precancerous adenomas to colorectal cancer (CRC), we generated single …
The tumor microenvironment (TME) is composed of many different cellular and acellular components that together drive tumor growth, invasion, metastasis, and response to …
M Ignatiadis, GW Sledge, SS Jeffrey - Nature reviews Clinical oncology, 2021 - nature.com
Historically, studies of disseminated tumour cells in bone marrow and circulating tumour cells in peripheral blood have provided crucial insights into cancer biology and the …
NF Greenwald, G Miller, E Moen, A Kong, A Kagel… - Nature …, 2022 - nature.com
A principal challenge in the analysis of tissue imaging data is cell segmentation—the task of identifying the precise boundary of every cell in an image. To address this problem we …