Advances in research on type 2 diabetes mellitus targets and therapeutic agents

J Su, Y Luo, S Hu, L Tang, S Ouyang - International Journal of Molecular …, 2023 - mdpi.com
Diabetes mellitus is a chronic multifaceted disease with multiple potential complications, the
treatment of which can only delay and prolong the terminal stage of the disease, ie, type 2 …

The contradictory role of branched-chain amino acids in lifespan and insulin resistance

H Yao, K Li, J Wei, Y Lin, Y Liu - Frontiers in Nutrition, 2023 - frontiersin.org
Branched-chain amino acids (BCAAs; a mixture of leucine, valine and isoleucine) have
important regulatory effects on glucose and lipid metabolism, protein synthesis and …

Depiction of branched-chain amino acids (BCAAs) in diabetes with a focus on diabetic microvascular complications

DM Tanase, EM Gosav, T Botoc, M Floria… - Journal of Clinical …, 2023 - mdpi.com
Type 2 diabetes mellitus (T2DM) still holds the title as one of the most debilitating chronic
diseases with rising prevalence and incidence, including its complications such as retinal …

What nutraceuticals can do for Duchenne muscular dystrophy: lessons learned from amino acid supplementation in mouse models

B De Paepe - Biomedicines, 2023 - mdpi.com
Duchenne muscular dystrophy (DMD), the severest form of muscular dystrophy, is
characterized by progressive muscle weakness with fatal outcomes most often before the …

Insulin Resistance and impaired branched-chain amino acid metabolism in Alzheimer's Disease

R Liu, L Zhang, H You - Journal of Alzheimer's Disease, 2023 - content.iospress.com
The pathogenesis of Alzheimer's disease (AD) is complicated and involves multiple
contributing factors. Mounting evidence supports the concept that AD is an age-related …

Association of serum albumin levels and long-term prognosis in patients with biopsy-confirmed nonalcoholic fatty liver disease

H Takahashi, M Kawanaka, H Fujii, M Iwaki, H Hayashi… - Nutrients, 2023 - mdpi.com
The relationship between baseline serum albumin level and long-term prognosis of patients
with nonalcoholic fatty liver disease (NAFLD) remains unknown. This is a sub-analysis of the …

Protein and amino acids in obesity: friends or foes?

Y Boirie, A Pinel, C Guillet - Current Opinion in Clinical Nutrition & …, 2023 - journals.lww.com
Interventions using dietary protein in obesity may be useful, especially during energy
restriction but also in sarcopenic obesity. Furthermore, metabolic profiles that encompass …

Overview of chromatographic and electrophoretic methods for the determination of branched‐chain amino acids

X Yin, E Adams… - Journal of Separation …, 2023 - Wiley Online Library
The significance of branched‐chain amino acids in diseases was clearly shown over the
years. This review aims to describe the available techniques for their analytical …

Leucine Supplementation Modulates Lipid Metabolism and Inflammation in Early Weaning Piglets

B Sun, Y Sun, Y Sun, X Zhou, X Han… - Journal of Agricultural …, 2024 - ACS Publications
Early weaning can induce the programmed dysregulation of glycolipid metabolism and
inflammation in adult animals. The primary objective of this study was to evaluate the …

[HTML][HTML] NMR analysis seeking for cognitive decline and dementia metabolic markers in plasma from aged individuals.

R Conde, N Oliveira, E Morais, AP Amaral… - … of Pharmaceutical and …, 2024 - Elsevier
Background Blood biomarkers can improve the ability to diagnose dementia, providing new
information to better understand the pathophysiology and causes of the disease. Some …