Despite increased global interest in testosterone deficiency in men and its treatment with
testosterone therapy, practical aspects of care remain confusing to many practitioners …

Background The effects of testosterone on cognitive function in older men are incompletely
understood. We aimed to establish the effects of long-term testosterone administration on …

Sex hormones are hypothesized to drive sex-specific health disparities. Here, we study the
association between sex steroid hormones and DNA methylation-based (DNAm) biomarkers …

Aging of humans is associated with functional alterations at all levels of the reproductive axis
and affects both steroidogenic and spermatogenic compartments. Unlike female …

Biological sex, fluctuations in sex steroid hormones throughout life and gender as a social
construct all influence every aspect of health and disease. Yet, for decades, most basic and …

Background: Testosterone treatment rates in adult men have increased in the United States
over the past 2 decades. Purpose: To assess the benefits and harms of testosterone …

Background The age‐related decline in testosterone levels is thought to be of great
importance for male aging and cardiovascular diseases. However, data are controversial on …

Background Cardiovascular calcification, characterized by deposition of calcium phosphate
in the arterial wall and heart valves, is associated with cardiovascular morbidity and mortality …

Total and free testosterone levels decline in men with advancing age due to defects at all
levels of the hypothalamic-pituitary-testicular axis. Age-related decline in total and free …

The number of older adults over 65 years of age is expected to increase to almost 100
million in the US by 2050, more than double the current figure of 46 million. Advanced age is …