Regulation of proteolysis plays a critical role in a myriad of important cellular processes. The
key to better understanding the mechanisms that control this process is to identify the …

Calpain is an intracellular Ca2+-dependent cysteine protease (EC 3.4. 22.17; Clan CA,
family C02). Recent expansion of sequence data across the species definitively shows that …

The ability to catalytically cleave protein substrates after synthesis is fundamental for all
forms of life. Accordingly, site-specific proteolysis is one of the most important post …

The caspases are unique proteases that mediate the major morphological changes of
apoptosis and various other cellular remodeling processes. As we catalog and study the …

The relatively common occurrence of sequences within proteins that match the consensus
substrate specificity of caspases in intracellular proteins suggests a multitude of substrates …

Reactivation of herpes simplex virus type 1 (HSV-1) from neuronal latency is a common and
potentially devastating cause of disease worldwide. CD8+ T cells can completely inhibit …

Proteases are enzymes that specifically cleave the peptide backbone of their target proteins.
As an important type of irreversible post-translational modification, protein cleavage …

We present a comprehensive and efficient gene set analysis tool, called 'GeneTrail'that
offers a rich functionality and is easy to use. Our web-based application facilitates the …

The activation of P2X7 receptor (P2X7R) on M1 polarized macrophages induces the
assembly of the NLRP3 inflammasome leading to the release of pro-inflammatory cytokines …

The linear ubiquitin chain assembly complex (LUBAC) is the only known E3 ubiquitin ligase
which catalyses the generation of linear ubiquitin linkages de novo. LUBAC is a crucial …