Accumulating evidence suggests that a high tumour burden has a negative effect on
anticancer immunity. The concept of tumour burden, simply defined as the total amount of …

Context The coronavirus disease 2019 (COVID-19) pandemic is leading to delays in the
treatment of many urologic cancers. Objective To provide a contemporary picture of the risks …

PURPOSE To provide recommendations for the management of patients with metastatic
clear cell renal cell carcinoma (ccRCC). METHODS An Expert Panel conducted a systematic …

Kidney cancer accounts for 5% and 3% of all adult malignancies in men and women,
respectively, thus representing the 7th most common cancer in men, and the 10th most …

Renal cell carcinomas vary considerably in their tumor biology and disease course, which is
reflected in the range of treatment paradigms in localized and metastatic renal cell …

Each year Clinical Cancer Advances: ASCO's Annual Report on Progress Against Cancer
highlights the most important clinical research advances of the past year, including the …

Background The CARMENA trial in patients with metastatic renal cell carcinoma (mRCC)
demonstrated that treatment with sunitinib alone was noninferior to cytoreductive …

Background Surgery for renal cell carcinoma (RCC) with venous tumour thrombus (VTT)
extension into the renal vein (RV) and/or inferior vena cava (IVC) has high peri-surgical …

Brain metastases are a challenging manifestation of renal cell carcinoma. We have a limited
understanding of brain metastasis tumor and immune biology, drivers of resistance to …

Simple Summary Over the past two decades, biological discoveries have transformed the
treatment strategies for renal cell carcinoma. These advances have led to the development …