The rapid and dynamic activation of the innate immune system is achieved through complex
signaling networks regulated by post-translational modifications modulating the subcellular …

The type I interferon (IFN‐I) system is important for antiviral and anticancer immunity.
Prolonged activation of IFN/JAK/STAT signaling is closely associated with autoimmune …

Porcine reproductive and respiratory syndrome virus (PRRSV) causes one of the most
economically important diseases of swine worldwide. Current antiviral strategies provide …

Prior studies have defined multiple, but inconsistent, roles for the enigmatic pattern
recognition receptor NLRX1 in regulating several cancer-associated biological functions. In …

ABSTRACT SARS-CoV-2 infections pose a global threat to human health and an
unprecedented research challenge. Among the most urgent tasks is obtaining a detailed …

Virulent Newcastle disease virus (NDV) is a violent infection in avian species. The
understanding of its pathogenic mechanism is consistently evolving along with the …

In mammals, cytosolic detection of nucleic acids is critical in initiating innate antiviral
responses against invading pathogens (like bacteria, viruses, fungi and parasites). These …

Abstract NOD-like receptor (NLR) X1 (NLRX1) is a negative regulator of inflammation by
inhibiting nuclear factor-κB (NF-κB) signaling and downstream pro-inflammatory factors …

RNA viral infections seriously endanger human health. Src homology 2 (SH2) domain-
containing protein tyrosine phosphatase 2 (SHP2) suppresses innate immunity against …

Receptors for activated C kinase 1 (RACK1) could competitively combine with mitochondrial
antiviral signaling protein (MAVS) to inhibit the type I interferon (IFN) signaling pathway …