Underlying mechanisms and related diseases behind the complex regulatory role of NOD-like receptor X1

H Shi, ZM Zhou, L Zhu, L Chen, ZL Jiang… - DNA and Cell …, 2022 - liebertpub.com
Among nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs), NOD-like
receptor X1 (NLRX1) is the only known NLR family member that is targeted to the …

Systematic profiling of a novel prognostic alternative splicing signature in hepatocellular carcinoma

D Zhang, Y Duan, Z Wang, J Lin - Oncology Reports, 2019 - spandidos-publications.com
Alternative splicing (AS) is a pervasive and vital mechanism involved in the progression of
cancer by expanding genomic encoding capacity and increasing protein complexity …

Black carp TRADD suppresses MAVS/IFN signaling during the innate immune activation

W Li, Y Cao, Z Chen, Y Tan, Y Dai, J Wei, J Xiao… - Fish & Shellfish …, 2021 - Elsevier
Tumor necrosis factor receptor 1 (TNFR1) associated death domain protein (TRADD) is a
pivotal adaptor in TNF signaling pathway and up-regulates MAVS/IFN signaling pathway in …

SARS-CoV-2 proteins exploit host's genetic and epigenetic mediators for the annexation of key host signaling pathways that confers its immune evasion and disease …

MAAK Khan, ABMMK Islam - BioRxiv, 2020 - biorxiv.org
The constant rise of the death toll and cases of COVID-19 has made this pandemic a serious
threat to human civilization. Understanding of host-SARS-CoV-2 interaction in viral …

[HTML][HTML] Focus on negatively regulated NLRs in inflammation and cancer

J Wang, W He, C Li, Y Ma, M Liu, J Ye, L Sun… - International …, 2024 - Elsevier
Nucleotide-binding and oligomerization structural domain (NOD)-like receptors (NLRs) play
an important role in innate immunity as cytoplasmic pattern recognition receptors (PRRs) …

DAK inhibits MDA5-mediated signaling in the antiviral innate immunity of black carp

G Liao, J Liu, L Yin, Y He, G Qiao, W Song, Y He… - Developmental & …, 2022 - Elsevier
Dihydroxyacetone kinase (DAK) functions as a negative regulator of melanoma
differentiation-associated gene 5 (MDA5)-mediated interferon (IFN) production in human. To …

Upregulation of FTX expression is associated with a poor prognosis and contributes to the progression of thyroid cancer

P Wang, Y Zhang, W Wang, H Jiang - Oncology Letters, 2021 - spandidos-publications.com
The dysregulated expression of long non‑coding RNA FTX transcript X inactive specific
transcript regulator (FTX) has been reported to be involved in the tumorigenesis of multiple …

Chromosome-scale assembly and population diversity analyses provide insights into the evolution of Sapindus mukorossi

T Xue, D Chen, T Zhang, Y Chen, H Fan… - Horticulture …, 2022 - academic.oup.com
Sapindus mukorossi is an environmentally friendly plant and renewable energy source
whose fruit has been widely used for biomedicine, biodiesel, and biological chemicals due …

Caprine MAVS is a RIG-I interacting type I interferon inducer downregulated by peste des petits ruminants virus infection

Q Miao, R Qi, C Meng, J Zhu, A Tang, D Dong, H Guo… - Viruses, 2021 - mdpi.com
The mitochondrial antiviral-signaling protein (MAVS, also known as VISA, IPS-1, or CARDIF)
plays an essential role in the type I interferon (IFN) response and in retinoic acid-inducible …

Protective or Problematic? Investigating the role of the innate immune receptor NLRX1 as a tumor suppressor or promoter in breast and pancreatic cancer.

MA Nagai-Singer - 2023 - vtechworks.lib.vt.edu
The innate immune system houses cellular signaling proteins called pattern recognition
receptors (PRRs) that are responsible for recognizing highly-conserved molecular patterns …