Poly (2-methacryloyloxyethyl phosphorylcholine) for protein conjugation

A Lewis, Y Tang, S Brocchini, J Choi… - Bioconjugate …, 2008 - ACS Publications
The water-soluble, biocompatible polymer poly (2-methacryloyloxyethyl phosphorylcholine)(
PMPC) was evaluated for protein conjugation. PMPC is a zwitterionic polymer that is able to …

Polycation-based gene therapy: current knowledge and new perspectives

MJ Tiera, Q Shi, FM Winnik… - Current gene …, 2011 - ingentaconnect.com
At present, gene transfection insufficient efficiency is a major drawback of non-viral gene
therapy. The 2 main types of delivery systems deployed in gene therapy are based on viral …

Efficient Encapsulation of Plasmid DNA in pH‐Sensitive PMPC–PDPA Polymersomes: Study of the Effect of PDPA Block Length on Copolymer–DNA Binding Affinity

H Lomas, J Du, I Canton, J Madsen… - Macromolecular …, 2010 - Wiley Online Library
We report the self‐assembly of a series of amphiphilic diblock copolymers comprising a
biocompatible, hydrophilic block, poly (2‐methacryloyloxyethyl phosphorylcholine)(PMPC) …

Biological soft materials

IW Hamley, V Castelletto - Angewandte Chemie International …, 2007 - Wiley Online Library
With one or two exceptions, biological materials are “soft”, meaning that they combine
viscous and elastic elements. This mechanical behavior results from self‐assembled …

Solution self‐assembly of tailor‐made macromolecular building blocks prepared by controlled radical polymerization techniques

JF Lutz - Polymer international, 2006 - Wiley Online Library
This review describes the preparation of colloidal aggregates (spherical micelles, cylindrical
micelles, polymer vesicles, multicompartment micelles, polyion complexes, schizophrenic …

Integrated functional nanocolloids covered with artificial cell membranes for biomedical applications

R Matsuno, K Ishihara - Nano Today, 2011 - Elsevier
The functionality of nanocolloids used in biomedical applications are subject to strong
interference arising from significant interactions with biological components such as proteins …

Synthetic and natural polycations for gene therapy: state of the art and new perspectives

MJ Tiera, FM Winnik, JC Fernandes - Current gene therapy, 2006 - ingentaconnect.com
Currently, the major drawback of gene therapy is the gene transfection rate. The two main
types of vectors that are used in gene therapy are based on viral or non-viral gene delivery …

Controlled delivery of antisense oligonucleotides: a brief review of current strategies

X Zhao, F Pan, CM Holt, AL Lewis… - Expert opinion on drug …, 2009 - Taylor & Francis
Antisense therapy has been investigated extensively over the past two decades, either
experimentally for gene functional research or clinically as therapeutic agents owing to the …

Ag NPs incorporated self-healable thermoresponsive hydrogel using precise structural “Interlocking” complex of polyelectrolyte BCPs: A potential new wound healing …

SL Banerjee, S Das, K Bhattacharya, M Kundu… - Chemical Engineering …, 2021 - Elsevier
There have been great interests in the development of new smart materials for the wound-
healing application. Herein, we have designed a new wound-healable material based on …

Synthesis and characterization of phosphorylcholine-substituted chitosans soluble in physiological pH conditions

MJ Tiera, XP Qiu, S Bechaouch, Q Shi… - …, 2006 - ACS Publications
A polymer analogous synthesis involving the reductive amination of phosphorylcholine
(PC)− glyceraldehyde with primary amines of deacetylated chitosan (M w≈ 57000 g mol-1) …