The improvement of biological properties of polycations is a fundamental step to overcome
their limitations as non-viral gene carriers. This work studied the effect of phosphorylcholine …

Polyelectrolyte complexes constituted by a linear charged homopolymeric chain and
oppositely charged copolymers with different topologies are investigated at the …

The increasing knowledge about the roles of different genes involved in both acquired and
hereditary diseases has made gene delivery an ever promising weapon in disease …

Abstract In this study, a 1, 4, 7, 10‐tetraazacyclododecane (cyclen)‐based side‐chain
homopolymer was developed for the first time; this polymer can self‐assembly with plasmid …

The effect of nanoparticle charge and conjugation to the cell penetrating peptide Tat on the
uptake of nanoparticles into MRC-5 fibroblasts was investigated using a range of advanced …

A facile, convenient and efficient approach for the synthesis of a new series of steroidal
heterocyclic compounds (4–12) by reacting a mixture of compounds (1e–3e) with o …

Biocompatible cationic polymers are attractive to many biomedical applications such as drug
or gene delivery. We have examined the interfacial adsorption and solution aggregation of …

The use of greener reducing, capping, and stabilizingagents (carbohydrates and their
momomers) is a new trend to avoid the toxic organic stabilizers in the preparation and …

Gene therapy is becoming promising for cancer treatment due to the rapid development of
knowledge in elucidating the molecular basis of cancers, as well as the availability of the …

This dissertation describes the research of bioreducible polymers for gene delivery. A series
of bioreducible poly (amido amine) s (PAAs) were synthesized. They complex with DNA …