Diarrhea is common in infants (children less than 2 years of age), usually acute, and, if
chronic, commonly caused by allergies and occasionally by infectious agents. Congenital …

We review the characteristics of SARS-CoV-2 infection in a large number of patients with IEI.
Overall, we found that combined immunodeficiencies, immune dysregulation disorders, and …

Common variable immunodeficiency (CVID) is the most frequent symptomatic primary
immunodeficiency characterized by recurrent infections, hypogammaglobulinemia and poor …

Autoimmune lymphoproliferative syndrome (ALPS) is an inherited syndrome characterized
by abnormal lymphocyte survival caused by failure of apoptotic mechanisms to maintain …

Primary immunodeficiencies (PIDs) are genetic disorders impairing host immunity, leading
to life-threatening infections, autoimmunity, and/or malignancies. Genomic technologies …

Abstract Selective IgA deficiency (SIgAD) is the most common primary immunodeficiency but
does not always result in clinical disease. This may in part be due to the definition based on …

Background Natural killer (NK) cells are critical innate effector cells whose development is
dependent on the Janus kinase–signal transducer and activator of transcription (STAT) …

Common variable immunodeficiency (CVID) is a primary B-cell immunodeficiency disorder,
characterized by remarkable hypogammaglobulinemia. The disease can develop at any age …

Evans syndrome (ES) is defined by the combination of autoimmune hemolytic anemia and
immune thrombocytopenia. Clinical presentation includes manifestations of immune …

Background Immune-dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX)
syndrome is a lethal disease caused by mutations in a transcription factor critical for the …