Decreased hippocampal synaptic plasticity is an important pathological change in stress-
related mood disorders, including major depressive disorder. However, the underlying …

Background: Lipids are essential components of the structure and for the function of brain
cells. The intricate balance of lipids, including phospholipids, glycolipids, cholesterol …

Recent studies have suggested that periodontal disease and alterations in the oral
microbiome may be associated with cognitive decline and Alzheimer's disease (AD) …

The “amyloid cascade” hypothesis of Alzheimer's disease (AD) pathogenesis invokes the
accumulation in the brain of plaques (containing the amyloid-β protein precursor [AβPP] …

Aging is the main risk factor of cognitive neurodegenerative diseases such as Alzheimer's
disease, with epigenome alterations as a contributing factor. Here, we compared …

In this issue of Neuron, Essayan-Perez and Südhof 1 demonstrate roles for γ-secretase in
the regulation of synaptic functions in human neurons. Chronic attenuation of γ-secretase …

Textbook models of synaptogenesis position cell adhesion molecules such as neurexin as
initiators of synapse assembly. Here we discover a mechanism for presynaptic assembly …

Alzheimer's disease (AD) is an age-related progressive neurodegenerative disease, and
approximately 10% of AD cases are early-onset familial AD (EOFAD), which is mainly linked …

The membrane raft accommodates the key enzymes synthesizing amyloid β (Aβ). One of the
two characteristic components of the membrane raft, cholesterol, is well known to promote …

Abstract Background Apolipoprotein E4 (ApoE4) allele is the strongest genetic risk factor for
late‐onset Alzheimer's disease, and it can aggravate depressive symptoms in non‐AD …