Cancer cells exhibit a dynamic metabolic landscape and require a sufficient supply of
nucleotides and other macromolecules to grow and proliferate. To meet the metabolic …

Nucleotides are the foundational elements of life. Proliferative cells acquire nutrients for
energy production and the synthesis of macromolecules, including proteins, lipids, and …

Skeletal muscle is greatly affected by aging, resulting in a loss of metabolic and physical
function. However, the underlying molecular processes and how (lack of) physical activity is …

Contemporary analyses of cell metabolism have called out three metabolites: ATP, NADH,
and acetyl-CoA, as sentinel molecules whose accumulation represent much of the purpose …

Critical to meeting cellular phosphorus (P) demand, soil bacteria deploy a number of
strategies to overcome limitation in inorganic P (Pi) in soils. As a significant contributor to P …

The focus of this review is the human de novo purine biosynthetic pathway. The pathway
enzymes are enumerated, as well as the reactions they catalyze and their physical …

Background Phosphorus (P) is one of the most essential macronutrients on the planet, and
microorganisms (including bacteria and archaea) play a key role in P cycling in all living …

To uncover underlying mechanisms associated with failure of indoleamine 2, 3-dioxygenase
1 (IDO1) blockade in clinical trials, we conducted a pilot, window-of-opportunity clinical study …

Over the past fifteen years, we have unveiled a new mechanism by which cells achieve
greater efficiency in de novo purine biosynthesis. This mechanism relies on the …

Summary (p) ppGpp is a nucleotide messenger universally produced in bacteria following
nutrient starvation. In E. coli, ppGpp inhibits purine nucleotide synthesis by targeting several …