MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer's disease

S Balusu, K Horré, N Thrupp, K Craessaerts, A Snellinx… - Science, 2023 - science.org
Neuronal cell loss is a defining feature of Alzheimer's disease (AD), but the underlying
mechanisms remain unclear. We xenografted human or mouse neurons into the brain of a …

[HTML][HTML] Role of primary aging hallmarks in Alzheimer´ s disease

J Zhao, J Huai - Theranostics, 2023 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is the most common neurodegenerative disease, which severely
threatens the health of the elderly and causes significant economic and social burdens. The …

Noncoding RNAs related to the hedgehog pathway in cancer: clinical implications and future perspectives

J Song, Y Ge, X Sun, Q Guan, S Gong, M Wei, J Niu… - Molecular cancer, 2022 - Springer
Cancer is a type of malignant affliction threatening human health worldwide; however, the
molecular mechanism of cancer pathogenesis remains to be elusive. The oncogenic …

Brain alarm by self-extracellular nucleic acids: From neuroinflammation to neurodegeneration

R Kunze, S Fischer, HH Marti, KT Preissner - Journal of Biomedical …, 2023 - Springer
Neurological disorders such as stroke, multiple sclerosis, as well as the neurodegenerative
diseases Parkinson's or Alzheimer's disease are accompanied or even powered by danger …

An ultrasensitive solid-state ECL biosensor based on synergistic effect between Zn-NGQDs and porphyrin-based MOF as “on-off-on” platform

C Dai, Y Gan, J Qin, L Ma, Q Liu, L Huang… - Colloids and Surfaces B …, 2023 - Elsevier
To develop an ultra-sensitive solid-state electrochemiluminescence (ECL) biosensor for
detection of miRNA 24, three different forms of porphyrin metal-organic framework (MOF) …

Role of piRNA biogenesis and its neuronal function in the development of neurodegenerative diseases

K Sato, K Takayama, S Inoue - Frontiers in Aging Neuroscience, 2023 - frontiersin.org
Neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD),
and amyotrophic lateral sclerosis (ALS), are caused by neuronal loss and dysfunction …

Identification of risk genes for Alzheimer's disease by gene embedding

Y Lagisetty, T Bourquard, I Al-Ramahi, CG Mangleburg… - Cell genomics, 2022 - cell.com
Most disease-gene association methods do not account for gene-gene interactions, even
though these play a crucial role in complex, polygenic diseases like Alzheimer's disease …

Circular RNA Pvt1 oncogene (CircPVT1) promotes the progression of papillary thyroid carcinoma by activating the Wnt/β-catenin signaling pathway and modulating …

L Zeng, S Yuan, P Zhou, J Gong, X Kong, M Wu - Bioengineered, 2021 - Taylor & Francis
Circular RNAs (circRNAs) have been reported to be involved in the progression of papillary
thyroid carcinoma (PTC). However, the role of circular RNA Pvt1 oncogene (circPVT1) in …

Circular RNAs in Alzheimer's disease: A new perspective of diagnostic and therapeutic targets

O Vakili, P Asili, Z Babaei, M Mirahmad… - CNS & Neurological …, 2023 - ingentaconnect.com
Background: Circular RNAs (circRNAs), as covalently closed single-stranded noncoding
RNA molecules, have been recently identified to involve in several biological processes …

Long non-coding RNAs, extracellular vesicles and inflammation in Alzheimer's disease

A Canseco-Rodriguez, V Masola, V Aliperti… - International Journal of …, 2022 - mdpi.com
Alzheimer's Disease (AD) has currently no effective treatment; however, preventive
measures have the potential to reduce AD risk. Thus, accurate and early prediction of risk is …