Background Laboratory testing is routinely used to assay blood biomarkers to provide
information on physiologic state beyond what clinicians can evaluate from interpreting …

Objective We examine international incidence trends of lung, colorectal, prostate, and breast
cancers, as well as all cancers combined excluding non-melanoma skin cancer (NMSC) in …

Importance If magnetic resonance imaging (MRI) mitigates overdiagnosis of prostate cancer
while improving the detection of clinically significant cases, including MRI in a screening …

Background Early detection of cancer aims to reduce cancer deaths. Unfortunately, many
established cancer screening technologies are not suitable for use in low-and middle …

Background Novel and non-invasive biomarkers with higher sensitivity and specificity for the
diagnosis of prostate cancer (PCa) is urgently needed. In this study, we used next …

Screening with a prostate-specific antigen (PSA) test could reduce death from prostate
cancer in some men but at the cost of substantial numbers overdiagnosed, as well as false …

Prostate cancer (PC) is one of the most common cancers in males and the fifth leading
reason of death. Age, ethnicity, family history, and genetic defects are major factors that …

Importance In April 2017, the US Preventive Services Task Force (USPSTF) published a
draft guideline that reversed its 2012 guidance advising against prostate-specific antigen …

The diagnostic and treatment landscapes of prostate cancer are rapidly evolving. This has
led to several challenges and controversies regarding optimal management of the disease …

The initial part of this review details the controversy behind the use of a serological level of
prostate-specific antigen (PSA) for the diagnostics of prostate cancer (PCa). Novel …