COVID-19 and Long COVID: Disruption of the Neurovascular Unit, Blood-Brain Barrier, and Tight Junctions

D Kempuraj, KK Aenlle, J Cohen… - The …, 2023 - journals.sagepub.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of
coronavirus disease 2019 (COVID-19), could affect brain structure and function. SARS-CoV …

Systems analysis of innate and adaptive immunity in Long COVID

MJ Peluso, M Abdel-Mohsen, TJ Henrich… - Seminars in …, 2024 - Elsevier
Since the onset of the COVID-19 pandemic, significant progress has been made in
developing effective preventive and therapeutic strategies against severe acute SARS-CoV …

[HTML][HTML] Recombinant SARS-CoV-2 spike protein stimulates secretion of chymase, tryptase, and IL-1β from human mast cells, augmented by IL-33

I Tsilioni, TC Theoharides - International Journal of Molecular Sciences, 2023 - mdpi.com
SARS-CoV-2 infects cells via its spike (S) protein binding to its surface receptor angiotensin-
converting enzyme 2 (ACE2) and results in the production of multiple proinflammatory …

Recombinant SARS-CoV-2 Spike Protein and its Receptor Binding Domain stimulate release of different pro-inflammatory mediators via activation of distinct receptors …

I Tsilioni, TC Theoharides - Molecular Neurobiology, 2023 - Springer
SARS-CoV-2 infects cells via its spike (S) protein binding to its surface receptor angiotensin
converting enzyme 2 (ACE2) on target cells and results in acute symptoms involving …

[HTML][HTML] Reviewing the potential links between viral infections and Tdp-43 proteinopathies

Z Rahic, E Buratti, S Cappelli - International Journal of Molecular …, 2023 - mdpi.com
Transactive response DNA binding protein 43 kDa (TDP-43) was discovered in 2001 as a
cellular factor capable to inhibit HIV-1 gene expression. Successively, it was brought to new …

[HTML][HTML] Amyloid precursor protein facilitates SARS-CoV-2 virus entry into cells and enhances amyloid-β-associated pathology in APP/PS1 mouse model of …

J Chen, J Chen, Z Lei, F Zhang, LH Zeng, X Wu… - Translational …, 2023 - nature.com
Although there are indications of a trend towards less severe acute respiratory symptoms
and a decline in overall lethality from the novel Coronavirus Disease 2019 (COVID-19) …

[HTML][HTML] TDP-43 Controls HIV-1 Viral Production and Virus Infectiveness

R Cabrera-Rodríguez, S Pérez-Yanes… - International journal of …, 2023 - mdpi.com
The transactive response DNA-binding protein (TARDBP/TDP-43) is known to stabilize the
anti-HIV-1 factor, histone deacetylase 6 (HDAC6). TDP-43 has been reported to determine …

[HTML][HTML] Kidney Damage in Long COVID: Studies in Experimental Mice

R Ramamoorthy, H Hussain, N Ravelo… - Biology, 2023 - mdpi.com
Simple Summary In this study, we investigated the long-term effects of COVID-19 on the
kidneys using mice infected with a similar coronavirus. We examined markers in the kidneys …

Gastrointestinal microbiota and metabolites possibly contribute to distinct pathogenicity of SARS-CoV-2 proto or its variants in rhesus monkeys

H Chen, J Wang, K Ding, J Xu, Y Yang, C Tang… - Gut …, 2024 - Taylor & Francis
Gastrointestinal (GI) infection is evidenced with involvement in COVID-19 pathogenesis
caused by SARS-CoV-2. However, the correlation between GI microbiota and the distinct …

Epigenetic memory of COVID-19 in innate immune cells and their progenitors

JG Cheong - 2023 - search.proquest.com
Systemic inflammation may trigger innate immune memory and persistent changes in
hematopoietic cells through epigenetic mechanisms, though investigating these phenotypes …