[HTML][HTML] New strategies of neurodegenerative disease treatment with extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs)

CP Palanisamy, JJ Pei, P Alugoju, NVA Anthikapalli… - Theranostics, 2023 - ncbi.nlm.nih.gov
Neurodegenerative diseases are characterized by the progressive loss of neurons and
intricate interactions between different cell types within the affected regions. Reliable …

[HTML][HTML] Directional induction of neural stem cells, a new therapy for neurodegenerative diseases and ischemic stroke

L Nie, D Yao, S Chen, J Wang, C Pan, D Wu… - Cell Death …, 2023 - nature.com
Due to the limited capacity of the adult mammalian brain to self-repair and regenerate,
neurological diseases, especially neurodegenerative disorders and stroke, characterized by …

[HTML][HTML] Astrocyte-derived extracellular vesicles for ischemic stroke: therapeutic potential and prospective

X Wang, A Li, H Fan, Y Li, N Yang, Y Tang - Aging and Disease, 2024 - ncbi.nlm.nih.gov
Stroke is a leading cause of death and disability in the world. Astrocytes are special glial
cells within the central nervous system and play important roles in mediating …

[HTML][HTML] New insights into the roles of oligodendrocytes regulation in ischemic stroke recovery

S Huang, C Ren, Y Luo, Y Ding, X Ji, S Li - Neurobiology of Disease, 2023 - Elsevier
Abstract Oligodendrocytes (OLs), the myelin-forming cells of the central nervous system, are
integral to axonal integrity and function. Hypoxia-ischemia episodes can cause severe …

Ursolic acid ameliorated neuronal damage by restoring microglia-activated MMP/TIMP imbalance in vitro

L Qiu, Y Wang, Y Wang, F Liu, S Deng… - Drug Design …, 2023 - Taylor & Francis
Purpose The oxygen and glucose deprivation-reoxygenation (OGDR) model is widely used
to evaluate ischemic stroke and cerebral ischemia-reperfusion (I/R) injury in vitro …

Oligodendrocyte progenitor cell-specific delivery of lipid nanoparticles loaded with Olig2 synthetically modified messenger RNA for ischemic stroke therapy

J Xu, R Wang, W Luo, X Mao, H Gao, X Feng, G Chen… - Acta Biomaterialia, 2024 - Elsevier
The transcription factor Olig2 is highly expressed throughout oligodendroglial development
and is needed for the differentiation of oligodendrocyte progenitor cells (OPCs) into …

Black phosphorus nanosheets suppress oxidative damage of stem cells for improved neurological recovery

F He, Z Liu, J Xu, Y Xiong, X Zhang, J Qi, X Lin… - Chemical Engineering …, 2023 - Elsevier
Stem cell transplantation has wide application prospects in tissue injury recovery, especially
in neurological recovery. However, the low survival rate of stem cells after transplanted to …

Olig2 ablation in immature oligodendrocytes does not enhance CNS myelination and remyelination

J Wang, L Yang, M Jiang, C Zhao, X Liu… - Journal of …, 2022 - Soc Neuroscience
The oligodendrocyte (OL) lineage transcription factor Olig2 is expressed throughout
oligodendroglial development and is essential for oligodendroglial progenitor specification …

[HTML][HTML] Novel insight into the role of A-kinase anchoring proteins (AKAPs) in ischemic stroke and therapeutic potentials

Z He, L Xie, J Liu, X Wei, W Zhang, Z Mei - Biomedicine & Pharmacotherapy, 2024 - Elsevier
Ischemic stroke, a devastating disease associated with high mortality and disability
worldwide, has emerged as an urgent public health issue. A-kinase anchoring proteins …

Lipid and Transcriptional Regulation in a Parkinson's Disease Mouse Model by Intranasal Vesicular and Hexosomal Plasmalogen‐based Nanomedicines

Y Wu, J Wang, Y Deng, B Angelov… - Advanced …, 2024 - Wiley Online Library
Plasmalogens (vinyl‐ether phospholipids) are an emergent class of lipid drugs against
various diseases involving neuro‐inflammation, oxidative stress, mitochondrial dysfunction …