Inflammasomes are critical sensors that convey cellular stress and pathogen presence to the
immune system by activating inflammatory caspases and cytokines such as IL-1β. The …

Abstract Absent in melanoma 2 (AIM2) is a cytoplasmic sensor that upon recognizing double-
stranded DNA assembles with apoptosis-associated speck-like protein containing a CARD …

Interferon (IFN)-inducible guanylate binding proteins (GBPs) mediate cell-autonomous host
resistance to bacterial pathogens and promote inflammasome activation. The prevailing …

The inflammasome is an important protein complex that cleaves the proinflammatory
cytokines pro-IL-1β and pro-IL-18 into their active forms. Owing to its critical role in eliciting …

Disease‐causing microorganisms not only breach anatomical barriers and invade tissues
but also frequently enter host cells, nutrient‐enriched environments amenable to support …

The immune system of multicellular organisms protects them from harmful microbes. To
establish an infection in the face of host immune responses, pathogens must evolve specific …

Sensing bacterial products in the cytosol of mammalian cells by NOD-like receptors leads to
the activation of caspase-1 inflammasomes, and the production of the pro-inflammatory …

Defense against bacterial infections requires activation of the immune response as well as
timely reestablishment of tissue and immune homeostasis. Instauration of homeostasis is …

Background BCG is recommended as intravesical immunotherapy to reduce the risk of
tumor recurrence in patients with non-muscle invasive bladder cancer (NMIBC). Currently, it …

GBPs are essential for immunity against intracellular pathogens, especially for Toxoplasma
gondii control. Here, the molecular interactions of murine GBPs (mGBP1/2/3/5/6), homo-and …