Modified ELISA for ultrasensitive diagnosis

N Tsurusawa, J Chang, M Namba, D Makioka… - Journal of Clinical …, 2021 - mdpi.com
An enzyme-linked immunosorbent assay (ELISA) can be used for quantitative measurement
of proteins, and improving the detection sensitivity to the ultrasensitive level would facilitate …

Exploring N-myristoyltransferase as a promising drug target against parasitic neglected tropical diseases

IJ dos Santos Nascimento, MAT Cavalcanti… - European Journal of …, 2023 - Elsevier
Neglected tropical diseases (NTDs) constitute a group of approximately 20 infectious
diseases that mainly affect the impoverished population without basic sanitation in tropical …

Polypharmacological cell-penetrating peptides from venomous marine animals based on immunomodulating, antimicrobial, and anticancer properties

S Hemmati, H Rasekhi Kazerooni - Marine Drugs, 2022 - mdpi.com
Complex pathological diseases, such as cancer, infection, and Alzheimer's, need to be
targeted by multipronged curative. Various omics technologies, with a high rate of data …

Epidemiological characteristics of Plasmodium malariae malaria in China: a malaria that should not be neglected post elimination

L Zhang, BY Yi, SS Zhou, ZG Xia… - Infectious Diseases of …, 2023 - mednexus.org
Background Plasmodium malariae was always neglected compared with P. falciparum and
P. vivax. In the present study, we aimed to describe the epidemiology of reported cases …

Selective whole-genome sequencing of Plasmodium parasites directly from blood samples by nanopore adaptive sampling

K De Meulenaere, WL Cuypers, JM Gauglitz… - Mbio, 2024 - Am Soc Microbiol
Whole-genome sequencing of Plasmodium is becoming an increasingly important tool for
genomic surveillance of malaria. Due to the predominance of human DNA in a patient blood …

Tuberculosis among ambulatory people living with HIV in Guangxi Province, China: a longitudinal study

Z Cui, F Huang, D Liang, Y Huang, H Qin, J Ye… - International Journal of …, 2022 - mdpi.com
Background: This study aims to determine the prevalence of TB among ambulatory people
living with HIV in Guangxi Province, which experienced the biggest HIV epidemic in China …

Inhibition of HIV-1 Protease by a Boronic Acid with High Oxidative Stability

BJ Graham, IW Windsor, RT Raines - ACS Medicinal Chemistry …, 2023 - ACS Publications
HIV-1 protease is an important target for pharmaceutical intervention in HIV infection.
Extensive structure-based drug design led to darunavir becoming a key chemotherapeutic …

HIV-Tocky system to visualize proviral expression dynamics

O Reda, K Monde, K Sugata, A Rahman… - Communications …, 2024 - nature.com
Determinants of HIV-1 latency establishment are yet to be elucidated. HIV reservoir
comprises a rare fraction of infected cells that can survive host and virus-mediated killing. In …

The human malaria-Aotus monkey model: a historical perspective in antimalarial chemotherapy research at the Gorgas Memorial Laboratory-Panama

N Obaldía III - Antimicrobial Agents and Chemotherapy, 2024 - Am Soc Microbiol
The human malaria-Aotus monkey model has served the malaria research community since
its inception in 1966 at the Gorgas Memorial Laboratory (GML) in Panama. Spanning over …

Indolyl‐4H‐Chromene Derivatives as Antibacterial Agents: Synthesis, in Vitro and in Silico Studies

P Anaikutti, P Adhikari, S Baskaran… - Chemistry & …, 2024 - Wiley Online Library
In this study, indolyl‐4H‐chromene derivatives are designed and synthesised using an eco‐
friendly multicomponent one‐pot synthesis using benzaldehydes, nitroketene N, S‐acetals …