Alzheimer's disease (AD) is a slowly progressing disorder in which pathophysiological
abnormalities, detectable in vivo by biomarkers, precede overt clinical symptoms by many …

Highlights•More than 40 loci of interest have been associated with the risk of developing
AD.•Recent genetic data clearly implicate microglia as involved in the pathophysiological …

Previous genome-wide association studies (GWAS), conducted by our group and others,
have identified loci that harbor risk variants for neurodegenerative diseases, including …

Germ-line genetic control of gene expression occurs via expression quantitative trait loci
(eQTLs). We present a large, exon-specific eQTL data set covering ten human brain regions …

The physiological balance between excitation and inhibition in the brain is significantly
affected in Alzheimer's disease (AD). Several neuroactive compounds and their signaling …

Pathological aggregation of tau is a hallmark of Alzheimer's disease and related
tauopathies. We have previously shown that the deficiency of the microglial fractalkine …

Abstract The Alzheimer's Disease Sequencing Project (ADSP) undertook whole exome
sequencing in 5,740 late-onset Alzheimer disease (AD) cases and 5,096 cognitively normal …

The transmembrane protein CD33 is a sialic acid-binding immunoglobulin-like lectin that
regulates innate immunity but has no known functions in the brain. We have previously …

The identification of subjects at high risk for Alzheimer's disease is important for prognosis
and early intervention. We investigated the polygenic architecture of Alzheimer's disease …

The complement system is an ancient collection of proteolytic cascades with well-described
roles in regulation of innate and adaptive immunity. With the convergence of a revolution in …